University of Groningen
The role of small conductance calcium-activated potassium channels in mitochondrial
dysfunction
Krabbendam, Inge
DOI:
10.33612/diss.144370526
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Krabbendam, I. (2020). The role of small conductance calcium-activated potassium channels in mitochondrial dysfunction: Targeting metabolic reprogramming and calcium homeostasis. University of Groningen. https://doi.org/10.33612/diss.144370526
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Propositions related to the present thesis Stellingen behorende bij het proefschrift
The role of small conductance calcium-activated potassium channels in mitochondrial dysfunction – Targeting metabolic reprogramming and calcium
homeostasis
1. Preconditioning mechanisms elicited by activation of mitochondrial KCa channels contribute to cellular protection against oxidative stress (this thesis).
2. Activation of SK channels provides neuroprotection in situations of glutamate-induced oxytosis, even under conditions where an increase in ER–mitochondrial coupling potentiates mitochondrial calcium influx and impairs mitochondrial respiration (this thesis).
3. Mitochondrial damage contributes to cell death pathway of ferroptosis in neuronal cells (this thesis).
4. SK channel activation enhances neuronal resilience against ferroptosis by initiating a metabolic shift towards glycolysis and inducing mitohormesis. Thereby, activation of SK channels promotes longevity and protection against mitochondrial stress in vivo (this thesis).
5. SK channel activation is able to reduce macrophage activity, thereby possibly reducing pro-inflammatory responses, a process potentially linked to inhibition of reverse electron transfer at mitochondrial complex I (this thesis).
6. Combination therapy of anti-cancer agent auranofin together with SK channel activation might be a promising therapy against glio- and neuroblastoma tumours (this thesis).
7. De tiid hâld gjin skoft (Frysian saying; ‘time does not pause’).
8. “The more you know, the more you realize you don’t know” – Aristotle 9. Doing a PhD is like running a (half) marathon; including the enthusiastic
start, trying to do more than you actually can, the hardest part in the end, but euphoria when finished.
