University of Groningen
Bio-organic hybrids of DNA, peptides and surfactants: from liquid crystals to molecular sleds
Zhang, Lei
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Publication date: 2017
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Zhang, L. (2017). Bio-organic hybrids of DNA, peptides and surfactants: from liquid crystals to molecular sleds. University of Groningen.
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Bio-organic hybrids of DNA, peptides
and surfactants: from liquid crystals to
molecular sleds
The work described in this thesis was carried out at the Zernike Institute for Advanced
Materials, University of Groningen, The Netherlands.
This work was supported financially by the European Research council (ERC) and the
Netherlands Organization for Scientific Research (NWO).
Printed by GVO drukkers & vormgevers B.V.
Bio-organic hybrids of DNA, peptides
and surfactants: from liquid crystals to
molecular sleds
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Friday 23 June 2017 at 16.15 hours
by
Lei Zhang
born on 16 February 1985
in Shandong, China
Supervisor
Prof. A. Herrmann
Assessment committee
Prof. W.H. Roos
Prof. N.H. Katsonis
Prof. A.P.H.J. Schenning
Zernike Insititute PhD thesis series 2017-15
ISSN: 1570-1530
ISBN: 978-90-367-9836-5 (Printed version)
978-90-367-9835-8 (electronic version)
To
Contents
Chapter 1 Solvent-free liquids and liquid crystals from biomacromolecules and a short introduction of a
molecular sled of pVIc... 1
Abstract ... 2
Introduction ... 3
Solvent-free nucleic acid liquids ... 4
Solvent-free protein liquids ... 9
Solvent-free virus liquids ... 19
Mechanism for the formation of solvent-free bio-liquids ... 21
Dynamic biomolecular hybrids - peptide sleds on DNA ... 22
Conclusions and outlook ... 23
Outline of this thesis ... 24
References ... 27
Chapter 2 Genetically engineered supercharged polypeptide fluids: fast and persistent self-ordering induced by a touch ... 31
Abstract ... 31
Introduction ... 32
Results and discussion ... 33
Conclusions ... 40
Experimental section ... 40
Supplementary figures ... 51
Reference ... 61
Chapter 3 Nematic DNA thermotropic liquid crystals with photo-responsive mechanical properties63 Abstract ... 63
Introduction ... 64
Results and discussion ... 65
Conclusions ... 73
Experimental section ... 73
Reference ... 92
Chapter 4 Speeding up biomolecular interactions by molecular sledding ... 95
Abstract ... 95
Introduction ... 96
Results and discussion ... 97
Conclusions ... 104
Experimental section ... 104
Supplementary Figures ... 107
References ... 119
Chapter 5 Accelerating Chemical Reactions by Molecular Sledding ... 121
Abstract ... 121
Introduction ... 122
Results and discussions ... 123
Conclusions ... 129
Supplementary figures ... 132
References ... 138
Summary ... 141
Samenvatting ... 144
