University of Groningen
Feasibility of cardiovascular population-based CT screening
Vonder, Marleen
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Publication date:
2018
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Vonder, M. (2018). Feasibility of cardiovascular population-based CT screening. Rijksuniversiteit
Groningen.
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Stellingen
behorende bij het proefschrift
1. There is a subtle balance in maintaining imaging biomarker validity of a Big-3 protocol and reducing the total radiation dose of such an acquisition. – Dit proefschrift 2. Although the coronary artery calcium score is the most validated imaging biomarker
in population-based studies, further standardization and optimization of the calcium score is required. – Dit proefschrift
3. Any change in the percentage of a population with a zero score resulting from adap-tation of the CT acquisition protocol should be avoided or reported. – Dit proefschrift 4. Before cardiovascular population-based CT screening can be implemented, a calcium
score imaging biomarker profile has to be established to ensure proper use of dose- reduced protocols. – Dit proefschrift
5. Radiation dose can be reduced with 48% in cardiovascular screening by using high-pitch spiral mode compared to sequential mode in participants with a regular (low and) high heart rate. – Dit proefschrift
6. Dose reduced protocols resulting in only minor reclassification rates can poten-tially be used in future population-based screening for CVD risk stratification.
– Dit proefschrift
7. In phantom studies, selective combinations of lower tube voltage and iterative reconstruction can reduce the radiation dose significantly with minor impact on the calcium score. – Dit proefschrift
8. Spectral shaping in coronary calcium scanning reduces the radiation dose but results in a lower detection of calcifications and lower Agatston scores, and therefore to underestimation of the cardiovascular risk in patients. – Dit proefschrift
9. CAC progression for different generations of dual-source CT can only be concluded if the Agatston score increases with >12.7%. – Dit proefschrift
10. De kwaliteit van de gezondheidszorg neemt toe door de inzet van technische geneeskundigen.
11. Voorkomen is beter dan genezen. – Desiderius Erasmus
12. You can keep going and your legs might hurt for a week, or you can quit and your mind will hurt for a lifetime. – Mark Allen
Marleen Vonder, 2018
