University of Groningen Coronary artery calcium in the population-based ImaLife study Xia, Congying

University of Groningen

Coronary artery calcium in the population-based ImaLife study

Xia, Congying

DOI:

10.33612/diss.136415357

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Publication date: 2020

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Citation for published version (APA):

Xia, C. (2020). Coronary artery calcium in the population-based ImaLife study: relation to cardiovascular risk factors and cognitive function. University of Groningen. https://doi.org/10.33612/diss.136415357

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Starting to write this part means that I am nearly at the last stage of my four years PhD journey, I would like to express my sincere appreciation to all of those who have contributed to this thesis and supported me in one and other ways.

At my younger age, I was always dreaming of a journey to the west. The opportuni-ty of becoming a PhD student at the Center for Medical Imaging, Universiopportuni-ty Medical Center of Groningen made my dream come true. Hereby, I would like to appreciate Prof. dr. M Oudkerk, for providing me with this opportunity. I still remember on the day of my interview at Groningen, professor Oudkerk described a future world of big data and imaging, which is quite impressive to me not only at that time point but also in my past four years. Your wisdom and unique insights in the field of imaging research, disease screening, and your spirits of international cooperation inspire me a lot.

I would like to express my sincere gratitude and appreciation to my first promo-tor, Prof. dr. Rozemarijn Vliegenthart. It has been a great honor working with you and being involved in the ImaLife study. Without your continuous supports and guidance, I would not have been able to complete this thesis. Your expertise is invaluable. Your insightful feedback motivates me to rethink critically and brings my research to a higher level. At a certain moment, I start to believe the power of a positive academic role model. Doing academic research is a journey of seeking the truth. I was so lucky to have you stood by me. Hope I can still do research with you in the near future.

My thanks also go to Dr. Marleen Vonder, my co-promotor, for all your contributions to this thesis. Thank you for sharing your knowledge about coronary artery calcium score, your experience of doing a PhD, and your time with me.

The assessment committee for this thesis, Prof. dr. J.L. Hillege, Prof. dr. A.H.E.M. Maas, and Prof. dr. C.H. Slump, is greatly appreciated.

I would like to express my gratitude to Prof. dr. P.P. De Deyn for your consultation on cognitive impairment and dementia; to Prof. dr. G.H. de Bock and Dr. G.A. Sido-renkov for your advice on statistical analyses and epidemiological study designs; to Erik Boersma for your collaboration and discussions on the skin autofluorescence project; to all co-authors for your valuable feedback, collaboration and contributions to researches that described in this thesis.

Dr. Estelle Noach, dear Stella, our ‘mother goose’, thank you so much for taking care of me during my PhD journey. Thank you for all your advice to my questions; all the notes you made during my progress meetings; all the parties you host for us; all the journal clubs and research meetings you organized; and especially, for

developing my can-do spirit. Thank you for being the person who I can always turn to for help.

Thanks to all my G2/Bloemsingel colleagues: Gert Jan Pelgrim, Wout Heerink, Randy van Dijk, Merel Kaatee, Marly van Assen, Mirjam Wielema, Monique Dor-rius, Marjolein Heuvelmans, Mieneke Rook, Paul Sijens, Jiapan Guo, Yeshaswini Nagaraj, Jiehui Chen, Daan van den Oever, Daan Ties, Daiwei Han, Runlei Ma, Sunyi Zheng, Rik Wisselink, Aniek Zwart, Xiaonan Cui, Pandji Triadyaksa, Lingyun Yu, Monique Koopman, Xueping Jing, Jiali Cai, Yihui Du, Bingjiang Qiu, Ivan Dudurych, Ricardo Rivas Loya, Ludo Cornelissen, for all the discussions, coffee breaks, dinners, drinks, and other activities. It was a great pleasure working with you. Especially, I would like to thank Yeshaswini Nagaraj for your food (please also pass my thanks to your husband for his breakfast recipe), encouragements and big warm hugs, and for taking care of me during all my troublesome days. Dr. Lingyun Yu and Dr. Jiapan Guo, thank you for sharing your experience with me. Also especially thanks to Merel Kaatee for your help with coronary artery calcium score; to Wout Heerink and Marly van Assen for your magical drinks; to Mieneke Rook, Gert Jan Pelgrim, Rik Wisselink and Jurjen van Bolhuis for your help with the ImaLife study; to Daan van den Oever for your help with all my Dutch phone calls and all the game nights at your place; to Mirjam Wielema for watching the choir and contemporary dance with me; to Yihui Du for your help with statistics; to Pandji Triadyaksa for inviting me to the book exhibition; and to all my Chinese colleagues for comforting my Chinese stomach.

Thanks to all ImaLife participants. For those more than 6000 Dutch participants, although we do not know each other, I have seen your hearts in black and white. It is a pity that I have not learned Dutch.

I would also like to thank all my friends for all the non-work related activities, I apologize that all your names are not enumerated here. Thanks to Bin Jiang, Cong Duan, and Yingying Cong for all the Euro tours we have had; to Tian Xie for all the running, cycling and fitness days we spent together; to Xiaoming Xu for taking care of me during my last days at Groningen.

I would like to acknowledge the support and great love of my family, my dear mama and baba. You start my life. There is no easy way to thank you for everything you have done for me. You always give me the strength to keep going, throughout my life. My long-lost the other half of me, we have known for a long time, thank you for being the reason I laugh with delight, and being an important part of my growth. For the past years, what I have done was trying to escape, even though I always know that is not the solution. There is only one true heroism in the world: to see the world

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as it is and to love it. I should be brave and strong. May the rest of our lives, never let go of love and hope.

It is the end of my PhD journey and a starter of a new chapter of my life. There is still a long way to go.

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Articles

Xia, C., Rook, M., Pelgrim, G. J., Sidorenkov, G., Wisselink, H. J., van Bolhuis, J. N., ... & Vliegenthart, R. (2020). Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study. European journal of epidemiology, 35(1), 75-86.

Xia, C., Vonder, M., Sidorenkov, G., Oudkerk, M., de Groot, J. C., van der Harst, P., ... & Vliegenthart, R. (2020). The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis. Journal of Atherosclerosis and Thrombosis, 52928.

Xia, C., Vonder, M., Pelgrim, G. J., Rook, M., Xie, X., Alsurayhi, A., ... & Vliegen-thart, R. (2020). High-pitch dual-source CT for coronary artery calcium scoring: A head-to-head comparison of non-triggered chest versus triggered cardiac acquisi-tion. Journal of Cardiovascular Computed Tomography.

van den Oever, L. B., Cornelissen, L., Vonder, M., Xia, C., van Bolhuis, J. N., Vlie-genthart, R., ... & van Ooijen, P. M. (2020). Deep learning for automated exclusion of cardiac CT examinations negative for coronary artery calcium. European Journal of Radiology, 109114.

Abstracts

Xia, C., Rook, M., Pelgrim, G. J., Van Bolhuis, J. N., Van Ooijen, P. M. A., Vonder, M., ... Vliegenthart, R. (2019). Age and gender distributions of coronary artery calci-um in the Dutch adult population: preliminary results of the ImaLife study. European Heart Journal, 40, 3208-3208.

Xia, C., Alsurayhi, A., Pelgrim, G. J., Rook, M., Vonder, M., Oudkerk, M., & Vlie-genthart, R. (2019). Agreement of coronary calcium scoring on chest CT and ECG triggered cardiac CT: a population-based study. European Heart Journal, 40, 858. Xia, C., Rook, M., Pelgrim, G. J., van Bolhuis, J. N., Van Ooijen, P., Vonder, M., ... & Vliegenthart, R. (2019, August). First results of a population-based study into prevalence and severity of coronary calcification as determined by third-generation dual-source computed tomography. ESCR Annual Scientific Meeting 2019.

a

Congying Xia was born on 19 July, 1993. In 2008, she commenced her study in clinical medicine at Tongji Medical College, Huazhong University of Science and Technology. In 2013, she was selected for a research master program, supervised by prof. Dao Wen Wang, in the Department of Cardiology, Tongji Hospital, Wuhan, China. She obtained her master degree with a thesis entitled “Myocardial energy metabolism and heart failure: the role of ACOT1 and its underlying mechanism”. In Oct 2016, she came to the Netherlands and started her PhD program focused on coronary artery calcium score, supervised by prof. Rozemarijn Vliegenthart and prof. Matthijs Oudkerk, at the University Medical Center Groningen.