University of Groningen
Coronary artery calcium in the population-based ImaLife study
Xia, Congying
DOI:
10.33612/diss.136415357
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Xia, C. (2020). Coronary artery calcium in the population-based ImaLife study: relation to cardiovascular risk factors and cognitive function. University of Groningen. https://doi.org/10.33612/diss.136415357
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Propositions accompanying the dissertation
Coronary artery calcium in the population-based ImaLife study: relation to
cardiovascular risk factors and cognitive function
1. Determining reference values for imaging biomarkers is fundamental to the development of CT screening-based risk assessment tools for Big-3 diseases. (this thesis)
2. Coronary calcium scoring can be performed reliably on high-pitch chest CT in non-obese individuals, allowing one chest CT acquisition for both lung and cardiac CT screening. (this thesis)
3. Adding the calcium score to the Systematic COronary Risk Evaluation (SCORE) can substantially impact cardiovascular risk classification. (this thesis)
4. A limited proportion of coronary artery calcium will be prevented if exposure to classical cardiovascular risk factors is eliminated. (this thesis)
5. The association between increased accumulation of advanced glycation end products and coronary artery calcium is largely explained by classical cardiovascular risk factors. (this thesis)
6. In clinical coronary artery disease, the risk of mild cognitive impairment and dementia is increased by 50%. Limited evidence supports that the calcium score is associated with the risk of dementia. (this thesis)
7. Dutch adults ≥45 years at a higher calcium score risk category have a worse cognitive performance of working memory. (this thesis)
8. Coronary calcium score is the best imaging biomarker of coronary artery disease but also has the potential in risk prediction of non-cardiovascular disease, namely, dementia. (this thesis) 9. A combined low-dose chest CT may possibly be used to obtain early imaging biomarkers of
Big-3 diseases in one scan.
10. All models are wrong but some are useful. - George E. P. Box
11. Superior doctors prevent the disease. Mediocre doctors treat the disease before evident. Inferior doctors treat the full blown disease. - Huang Dee: Nai-Ching (2600 B.C. 1st Chinese Medical Text.) 【是故圣人不治已病治未病，不治已乱治未乱，此之谓也。——《黄帝
内经•素问》】
