University of Groningen
Regulatory properties of lactic acid bacteria for improving immune homeostasis
Ren, Shengcheng
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Ren, S. (2019). Regulatory properties of lactic acid bacteria for improving immune homeostasis. University
of Groningen.
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Propositions associated with the dissertation
Regulatory properties of lactic acid bacteria
for improving immune homeostasis
1. Specific lactic acid bacteria can signal via toll-like receptor (TLR)2 pathway, especially TLR2/TLR6 but not TLR2/TLR1 pathway (this thesis).
2. Lactic acid bacteria secreted bioactive factors can exert immune-regulatory effects but their effects may be different from the bacterial strains per se (this thesis). 3. Lactic acid bacteria need to be alive to impact goblet cell functions (this thesis). 4. Bioactive factors released by specific lactic acid bacteria strains can be designed as mucus barrier-supportive foods (this thesis).
5. Lactic acid bacteria can impact goblet cell functions not only under homeostatic condition but also in disease (this thesis).
6. Fibroblasts play a key role in mucus barrier regulation and therefore should be included in cell models for in vitro evaluation of mucus-supportive potentials of lactic acid bacteria (this thesis).
7. To achieve the best clinical efficacy, viability, administration dose, and timing of lactic acid bacteria should be optimized (this thesis).
8. Every snowflake is unique, yet they are each perfect (Donald L. Hicks, excerpted from Look Into the Stillness). 9. You can never tell a book by its cover
(Edwin Rolfe and Lester Fuller, excerpted from Murder in the Glass Room).
