University of Groningen
Regulatory properties of lactic acid bacteria for improving immune homeostasis Ren, Shengcheng
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Publication date: 2019
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Ren, S. (2019). Regulatory properties of lactic acid bacteria for improving immune homeostasis. University of Groningen.
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530789-L-bw-Ren 530789-L-bw-Ren 530789-L-bw-Ren 530789-L-bw-Ren Processed on: 17-4-2019 Processed on: 17-4-2019 Processed on: 17-4-2019
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Regulatory properties of lactic acid
bacteria for improving immune
homeostasis
530789-L-bw-Ren 530789-L-bw-Ren 530789-L-bw-Ren 530789-L-bw-Ren Processed on: 17-4-2019 Processed on: 17-4-2019 Processed on: 17-4-2019
Processed on: 17-4-2019 PDF page: 2PDF page: 2PDF page: 2PDF page: 2 Printing of this thesis was financially supported by:
University Medical Center Groningen University of Groningen
Graduate School of Medical Sciences
Cover design: Hongguang Zhang&Shengcheng Ren
Lay-out: Shengcheng Ren
Printed by: Ipskamp Printing ISBN (printed):978-94-034-1641-0
ISBN (digital): 978-94-034-1640-3
© Copyright 2019 Shengcheng Ren, Groningen, The Netherlands All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
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Regulatory properties of lactic acid
bacteria for improving immune
homeostasis
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 3 June 2019 at 11.00 hours By
Shengcheng Ren
Born on 5 August 1989 in Anhui, China
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Supervisor
Prof. P. de Vos
Co-supervisor
Dr. M.M. Faas
Assessment Committee
Prof. H.J. Wichers
Prof. K.N. Faber
Prof. J. Kok
Paranymphs
Chunli Kong
Susana Figueroa-Lozano
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Table of contents
Chapter 1
Disease managing capacities and mechanisms of host effects of lactic acid bacteria9 Design and rationale of this thesis 39
Chapter 2
Identification of TLR2/TLR6 signalling lactic acid bacteria for supporting immune regulation53
Chapter 3
Lactic acid bacteria secrete Toll like receptor 2 stimulating and immunomodulating bioactive factors81
Chapter 4
Protective effects of lactic acid bacteria on gut epithelial barrier dysfunction are Toll like receptor 2 and protein kinase C dependent99
Chapter 5
Lactic acid bacteria may impact intestinal barrier function by modulating goblet cells113
Chapter 6
Fibroblasts impact goblet cell responses to lactic acid bacteria after exposure to inflammatory cytokines and mucus disruptors145
Chapter 7
General discussion and future perspective 175
Appendices
Summary Nederlandse samenvatting Acknowledgements Biography List of publications 185530789-L-bw-Ren 530789-L-bw-Ren 530789-L-bw-Ren 530789-L-bw-Ren Processed on: 17-4-2019 Processed on: 17-4-2019 Processed on: 17-4-2019
