University of Groningen
The consequences of aneuploidy and chromosome instability
Schukken, Klaske Marijke
DOI:
10.33612/diss.135392967
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Publication date: 2020
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Schukken, K. M. (2020). The consequences of aneuploidy and chromosome instability: Survival, cell death and cancer. University of Groningen. https://doi.org/10.33612/diss.135392967
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The Consequences of Aneuploidy
and Chromosome Instability
Survival, Cell Death and Cancer
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Monday 13 January 2020 at 14.30 hours
by
Klaske Marijke Schukken
born on 18 December 1991 in Guelph, Canada
The Consequences of Aneuploidy
and Chromosome Instability
Survival, Cell Death and Cancer
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Monday 13 January 2020 at 14.30 hours
by
Klaske Marijke Schukken
born on 18 December 1991 in Guelph, Canada
The Consequences of Aneuploidy
and Chromosome Instability
Survival, Cell Death and Cancer
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Monday 13 January 2020 at 14.30 hours
by
Klaske Marijke Schukken
born on 18 December 1991 in Guelph, Canada © copyright Klaske Marijke Schukken, Groningen 2020
Printing: ProefschriftMaken || www.proefschriftmaken.nl
ISBN 978-94-6380-609-1 All rights reserved. No part of this publication may be reproduced, stored in a
retrieval system or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission of the author or the copyright-owning journals for previous published chapters.
The Consequences of Aneuploidy
and Chromosome Instability
Survival, Cell Death and Cancer
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Monday 13 January 2020 at 14.30 hours
by
Klaske Marijke Schukken
born on 18 December 1991 in Guelph, Canada
Supervisor
Prof. F. Foijer Prof. G. de HaanAssessment Committee
Prof. M.A.T.M. van Vugt
Prof. C.F. Calkhoven
Prof. S.M.A.Lens
Table of Contents
Chapter
1
5
General introduction and chapter outlines
Chapter
2
11
CIN and aneuploidy: different concepts, different consequences
Chapter
3
29
Altering microtubule dynamics is synergistically toxic with inhibition of
the spindle assembly checkpoint
Chapter
4
69
CIN tracker- a novel mouse model to monitor mitosis in vivo
Chapter
5
89
Aneuploidy tracker- a novel mouse model to track aneuploidy in live
cells
Chapter
6
114
Differential tissue tolerance for Mad2 spindle assembly checkpoint
knockout in mice
Chapter
7
132
Summary, discussion and future directions
Bibliography 140
Appendix
162
Abbreviations and definitions
Nederlandse samenvatting
Acknowledgements
CV & list of publications
Table of Contents
Chapter 1
7
General introduction and chapter outlines
Chapter 2
13
CIN and aneuploidy: different concepts, different consequences
Chapter 3
31
Altering microtubule dynamics is synergistically toxic with inhibition of the spindle checkpoint
Chapter 4
73
CIN tracker- a novel mouse model to monitor mitosis in vivo
Chapter 5
95
Aneuploidy tracker- a novel mouse model to track aneuploidy in live cells
Chapter 6
121
Differential tissue tolerance for Mad2 spindle assembly checkpoint knockout in mice
Chapter 7
141
Summary, Discussions and Future Directions
Bibliography 149
Appendix 171
Abbreviations and definitions Nederlandse samenvatting Acknowledgements CV & list of publications
Supervisor
Prof. F. Foijer Prof. G. de Haan
