University of Groningen
The consequences of aneuploidy and chromosome instability
Schukken, Klaske Marijke
DOI:
10.33612/diss.135392967
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Schukken, K. M. (2020). The consequences of aneuploidy and chromosome instability: Survival, cell death and cancer. University of Groningen. https://doi.org/10.33612/diss.135392967
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Stellingen behorende bij het proefschrift
The Consequences of Aneuploidy and Chromosome Instability: Survival, Death and Cancer
1) Chromosomal instability (CIN) and aneuploidy are similar concepts but not synonymous. CIN is the process that leads to chromosome copy number alterations, and aneuploidy is the result. (This thesis)
2) To better understand which CIN rates in cancer drive further evolution towards therapy resistance and which CIN rates are toxic for tumor progression, we need better tools to quantify CIN rates in vivo. (This thesis) 3) Combining SAC inhibition with tubulin deregulation is synergistically toxic to cells and might provide a powerful means to target cancer cells with a CIN phenotype. (This thesis)
4) The CIN tracker mouse model can be used to assess and better understand the rates and types of chromosome mis-segregation taking place in vivo within living cells in various tissues or tumors, at multiple time points and within a variety of genetic backgrounds without having to take cells ex vivo. (This thesis)
5) CIN has vastly different effects on different tissues. (This thesis)
6) Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less. (Marie Curie)
7) The good thing about science is that it’s true whether or not you believe in it. (Niel DeGrasse Tyson)
8) While we might someday be able to cure most cancers, we will never be able to cure all. Ongoing DNA damage and CIN generates constant micro-evolution that researchers will not be able to fully counter.
9) Biology is always more complicated.
10) Killing cancer is easy, killing cancer without also killing the patient is a lot harder.
