University of Groningen
Exploring optimal pharmacotherapy after bariatric surgery: where two worlds meet
Yska, Jan Peter
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Publication date: 2017
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Yska, J. P. (2017). Exploring optimal pharmacotherapy after bariatric surgery: where two worlds meet. Rijksuniversiteit Groningen.
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EXPLORING OPTIMAL PHARMACOTHERAPY
AFTER BARIATRIC SURGERY:
WHERE TWO WORLDS MEET
Publication of this thesis was financially supported by the MCL Academie, Medical Centre Leeuwarden.
Yska, Jan Peter
Exploring optimal pharmacotherapy after bariatric surgery: where two worlds meet. Thesis Groningen University – with summary in Dutch
Cover and layout design Mirjam Leppers, Persoonlijkproefschrift.nl Printed by Gildeprint, Enschede, The Netherlands
ISBN 978-90-367-9756-6 (book)
ISBN 978-90-367-9755-9 (digital version)
©2017 Jan Peter Yska
All rights reserved. No part of this book may be reproduced in any form without written permission of the author.
EXPLORING OPTIMAL PHARMACOTHERAPY
AFTER BARIATRIC SURGERY: WHERE TWO WORLDS MEET
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op vrijdag 2 juni om 12.45 uur
door
Jan Peter Yska
geboren op 25 juni 1959PROMOTORES
Prof. dr. E.N. van Roon Prof. dr. B. Wilffert
BEOORDELINGSCOMMISSIE
Prof. dr. C.A.J. Knibbe Prof. dr. E.F.C. van Rossum Prof. dr. D.J. Touw
C O N T E N T S
SECTION I INTRODUCTION
Chapter 1 General introduction
SECTION II (PHARMACO)EPIDEMIOLOGY
Chapter 2 Influence of bariatric surgery on the use
and pharmacokinetics of some major drug classes Chapter 3 Influence of bariatric surgery on the use of medication Chapter 4 Remission of type 2 diabetes mellitus in patients after different types of bariatric surgery: a population-based cohort study in the United Kingdom
SECTION III OPTIMIZATION OF PHARMACOTHERAPY AFTER BARIATRIC SURGERY
Chapter 5 NSAID use after bariatric surgery:
a randomized controlled intervention study
SECTION IV BIOAVAILABILITY OF METOPROLOL
Chapter 6 A gastrointestinal simulation system
for dissolution of oral solid dosage forms before and after Roux-en-Y gastric bypass
Chapter 7 A validated high-resolution accurate mass LC-MS assay for quantitative determination of metoprolol and α-hydroxymetoprolol in human serum for
application in pharmacokinetics
Chapter 8 Effect of Roux-en-Y gastric bypass on the
bioavailability of metoprolol from immediate and controlled-release tablets: a single oral dose study before and after surgery
11 25 41 57 81 97 113 131
SECTION V CONCLUSIONS AND PERSPECTIVES
Chapter 9 General discussion and future perspectives
APPENDICES
Samenvatting (synopsis in Dutch)
Tot slot
Curriculum vitae
List of co-authors List of publications related to the thesis
157 173 183 187 189 193
9
