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University of Groningen

On the mechanism of membrane transport of zinc ions by ZntB Stetsenko, Artem

DOI:

10.33612/diss.113452953

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Stetsenko, A. (2020). On the mechanism of membrane transport of zinc ions by ZntB. University of Groningen. https://doi.org/10.33612/diss.113452953

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PROPOSITIONS

belonging to the thesis

On the membrane transport mechanism of zinc ions by ZntB

by

Artem Stetsenko

1. The 2-TM-GxN family consists of both channels and transporters (Chapter 2, 3 and 4). 2. ZntB is a zinc ion importer, driven by a proton gradient (Chapter 2 and 3).

3. ZntB is a stable symmetrical pentamer in the apo-state in contrast to CorA (Chapter 2). 4. Amino acid Glu253 in ZntB is most likely responsible for proton coupling (Chapter 3). 5. CorA can transport the same ions as ZntB with similar Km values (Chapter 4).

6. n-Dodecyl-β-D-maltopyranoside (DDM) is the most commonly used detergent for solubilization of membrane proteins and further studies (Chapter 5).

7. Sometimes, reviews with the general information are more valuable to scientific community than detailed long-term research (Chapter 5).

8. Our world has more and more information, and less and less meaning. Inspired by Jean Baudrillard

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