Bone marrow derived cells in collateral formation : studies toward therapeutic arteriogenesis
Hellingman, A.A.
Citation
Hellingman, A. A. (2011, September 15). Bone marrow derived cells in collateral formation : studies toward therapeutic arteriogenesis. Retrieved from https://hdl.handle.net/1887/17838
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17838
Note: To cite this publication please use the final published version (if
applicable).
Bone marrow derived cells in collateral formation:
studies toward therapeutic arteriogenesis
Alwine Hellingman
ISBN: 978-94-6169-117-0 A.A. Hellingman 2011
Cover: Males ‘Red Sentinel’, Schuddebeurs 2008 by K.W. Hellingman-van Holten Cover design: Optima Grafische Communicatie, Rotterdam
Layout and printing: Optima Grafische Communicatie, Rotterdam, The Netherlands
Bone marrow derived cells in collateral formation:
studies toward
therapeutic arteriogenesis
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 15 september 2011
klokke 15:00 uur door
Alwine Antoinette Hellingman geboren te Den Haag in 1981
PROMOTIECOMMISSIE
Promotores: Prof. Dr. P.H.A. Quax Prof. Dr. J.F. Hamming
Overige leden: Prof. Dr. J.H. van Bockel Prof. Dr. W.E. Fibbe Prof. Dr. J.W. Jukema Prof. Dr. J. Kuiper
Publication of this thesis was sponsored by Chipsoft Bronovo Researchfonds, J.E. Juri- aanse stichting. Financial support for printing of this thesis by the Dutch Heart Founda- tion is gratefully acknowledged.
Luctor et Emergo
– Ik worstel en kom boven-
Voor mijn ouders, Boudewijn, Jurriaan en Julius
Contents
1. General introduction 9
INFLAMMATORY KEY PLAYERS IN ARTERIOGENESIS AND EXPERIMENTAL MODELS FOR PERIPHERAL ARTERY DISEASE 2. Review: Bone marrow derived cells in arteriogenesis:
the role of inflammatory cells
Deindl E and Schaper W, editors. Arteriogenesis – Molecular Regulation, Pathophysiology and Therapeutics. E-book.
23
3. Variations in surgical procedures for hind limb ischemia mouse models result in differences in collateral formation.
Eur J Vasc Endovasc Surg. 2010 Dec;40(6):796–803
37
ROLE OF BONE MARROW DERIVED CELLS AND INFLAMMATORY CELLS IN ARTERIOGENESIS
4. Molecular imaging of bone marrow mononuclear cell survival and homing in a murine model of peripheral artery disease.
JACC Cardiovascular Imaging. 2011. In press
55
5. T-cell-pre-stimulated monocytes promote neovas- cularization in a murine hind limb ischemia mouse model.
Eur J Vasc Endovasc Surg. 2011. In press
73
6. Protease-activated-receptor-2 rather than protease- activated-receptor-1 plays a crucial role in arteriogen- esis.
Submitted for publication
91
7. A limited role of regulatory T cells in post-ischemic neovascularization.
J Cell Mol Med. 2011. In press
109
GENE THERAPY FOR THERAPEUTIC ARTERIOGENESIS 8. Gene silencing of prolyl hydroxylase-2 using a
minicircle vector carrying short hairpin RNA against PHD2 improves post-ischemic neovascularization.
In preparation
131
9. General discussion and summary 149
10. Nederlandse samenvatting 159
11. Curriculum vitae en dankwoord 165
