Biological properties of the oncoproteins E6 and E7 from mucosal and
cutaneous HPV types
Dong, W.L.
Citation
Dong, W. L. (2006, November 14). Biological properties of the oncoproteins E6 and E7
from mucosal and cutaneous HPV types. Retrieved from https://hdl.handle.net/1887/4979
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from:
https://hdl.handle.net/1887/4979
Biological properties of
the oncoproteins E6 and E7
from mucosal and cutaneous
HPV types
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Dr.D.D.Breimer,
hoogleraar in de faculteit der Wiskunde en
Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties
te verdedigen op dinsdag 14 november 2006
klokke 13:45 uur
door
Wen Liang Dong
Promotiecommissie
Promotor: Prof. Dr. W.J.M. Spaan
Co-promotor: Dr. M. Tommasino (International Agency for Research on Cancer, France) Referent: Prof. Dr. H. Pfister (University of Cologne, Germany)
Overige leden: Prof. Dr. C.J.M. Melief Dr. L. Struijk
ISBN-10: 90-8559-242-9 ISBN-13: 978-90-8559-242-6 Dong, Wen Liang
Biological properties of the oncoproteins E6 and E7 from mucosal and cutaneous HPV types Thesis, Leiden University Medical Center
November 14, 2006 © Wen Liang Dong
CONTENTS
Chapter 1 General Introduction 7
Chapter 2 Determination of the binding affinity of different human papillomavirus E7 proteins for the tumour suppressor pRb by a plate-binding assay
45
Chapter 3 Human Papillomavirus Type 32 Does Not Display in
vitro Transforming Properties 55
Chapter 4 Skin Hyperproliferation and Susceptibility to Chemical Carcinogenesis in Transgenic Mice Expressing E6 and E7 of Human Papillomavirus type 38
65
Chapter 5 Skin human papillomavirus type 38 alters p53
functions by accumulation of �Np73 77
Chapter 6 General Discussion 87
Summary – Samenvatting 99
