Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins
Ke, P.
Citation
Ke, P. (2011, September 14). Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins. Retrieved from https://hdl.handle.net/1887/17833
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17833
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Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op 14 September 2011 klokke 13.45 uur
door Ke Peng
geboren te Dalian, China in 1981.
1
Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins
Ke Peng
2
Promoter: Prof. Dr. Ir. Johannes G.E.M. (Hans) Fraaije Co-promoter: Dr. Alexander Kros
Ke Peng
Hydrogel based drug carriers for controlled release of hydrophobic drugs and proteins Leiden Institute of Chemistry, Leiden University, the Netherlands
September 2011
ISBN: 978-90-8570-782-0
Printing: WÖHRMANN PRINT SERVICE, Zutphen, the Netherlands.
3
Contents
1. General introduction 4
2. Cyclodextrin–dextran based in situ hydrogel formation: 9
a carrier for hydrophobic drugs 3. Cyclodextrin/dextran based drug carriers for a controlled release of 22
hydrophobic drugs in zebrafish embryos 4. In situ forming covalently crosslinked albumin/dextran hydrogel 42
as a drug carrier 5. Light controlled protein release from a supramolecular hydrogel 56
6. Dextran based photodegradable hydrogels formed via a Michael addition 71
7. Summary and perspectives 92
Appendix A Nederlandse samenvatting 97
Appendix B Curriculum vitae & List of publications 103
Appendix C Acknowledgement 106
Appendix D The synthesis of heterobifunctional linker based on 109 N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
