University of Groningen
Ambulatory assessment of human circadian phase and related sleep disorders from heart
rate variability and other non-invasive physiological measurements
Gil Ponce, Enrique
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Publication date: 2017
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Gil Ponce, E. (2017). Ambulatory assessment of human circadian phase and related sleep disorders from heart rate variability and other non-invasive physiological measurements. University of Groningen.
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Ambulatory assessment of human
circadian phase and related sleep
disorders from heart rate variability
and other non-invasive
physiological measurements
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Friday 28 April 2017 at 16.15 hours
by
Enrique Antonio Gil Ponce
born on 16 September 1985
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Supervisors
Prof. D.G.M. Beersma
Prof. R.A. Hut
Co-supervisor
Dr. X. Aubert
Assessment Committee
Prof. M.J.H. Kas
Prof. E. van Someren
Prof. P. Achermann
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The research presented in this thesis has been performed at Philips Research in Eindhoven and partly at the University of Groningen, Charité University Hospital and the Advanced Sleep Research center in Berlin.
Financial support was provided by the EU FP7 Marie Curie Network iCareNet under grant number 264738.
© 2017 Enrique A. Gil
Layout and Cover Design: Enrique A. Gil Printing: Zalsman Groningen B.V.
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Table of Contents
1
ASSESSING THE STATE OF THE HUMAN CIRCADIAN CLOCK IN
AMBULATORY CONDITIONS: A REVIEW OF MODELS DRIVEN BY
NON-INVASIVE MEASUREMENTS ... 9
1.1 Abstract ... 10
1.2 Introduction ... 10
1.3 Non-invasive Circadian Signals ... 19
1.4 Circadian Phase Estimation Models ... 23
1.5 Discussion ... 29
1.6 Conclusion ... 31
1.7 Acknowledgements ... 33
1.8 References ... 33
2
HUMAN CIRCADIAN PHASE ESTIMATION FROM SIGNALS
COLLECTED IN AMBULATORY CONDITIONS USING AN
AUTOREGRESSIVE MODEL ... 39
2.1 Abstract ... 40
2.2 Introduction ... 40
2.3 Materials and Methods ... 42
2.4 Results ... 48
2.5 Discussion ... 53
2.6 Acknowledgement ... 55
2.7 References ... 55
3
ADDENDUM: CIRCADIAN PHASE ESTIMATION OF HEALTHY
SUBJECTS USING HEART RATE-, LIGHT- AND LOCOMOTOR
ACTIVITY-DERIVED FEATURES ... 61
3.1 Abstract ... 62
3.2 Introduction ... 62
3.3 Materials and Methods ... 63
3.4 Results ... 64
3.5 Discussion ... 65
6
4
AMBULATORY ESTIMATION OF HUMAN CIRCADIAN PHASE USING
MODELS OF VARYING COMPLEXITY BASED ON NON-INVASIVE SIGNAL
MODALITIES ... 67
4.1 Abstract ... 68 4.2 Introduction ... 68 4.3 Methods ... 69 4.4 Results ... 72 4.5 Discussion ... 73 4.6 Conclusion ... 75 4.7 Acknowledgements ... 76 4.8 References ... 765
ENDOGENOUS CIRCADIAN PHASE ESTIMATION USING HEART
RATE-DERIVED FEATURES EXTRACTED FROM AMBULATORY
ELECTROCARDIOGRAPHY AND A WRIST-WORN OPTICAL HEART RATE
SENSOR ... 79
5.1 Abstract ... 80
5.2 Introduction ... 80
5.3 Materials and Methods ... 81
5.4 Results ... 85
5.5 Discussion ... 89
5.6 Conclusion ... 91
5.7 Acknowledgements ... 91
5.8 References ... 91
6
ALTERED TEMPORAL INDICES OF HEART RATE VARIABILITY IN
SLEEP ONSET INSOMNIA ... 95
6.1 Abstract ... 96
6.2 Introduction ... 96
6.3 Materials and Methods ... 97
6.4 Results ... 99
6.5 Discussion ... 103
6.6 Conclusion ... 106
6.7 Acknowledgements ... 106
7
7
CIRCADIAN PHASE ESTIMATION OF SLEEP ONSET INSOMNIA
PATIENTS ... 111
7.1 Abstract ... 112 7.2 Introduction ... 112 7.3 Methods ... 113 7.4 Results ... 115 7.5 Discussion ... 117 7.6 Conclusion ... 118 7.7 Acknowledgments ... 119 7.8 References ... 1198
DISCUSSION AND FUTURE RESEARCH ... 121
8.1 Signal modalities ... 122
8.2 Mathematical models ... 124
8.3 Subject populations... 126
8.4 Limitations and future research ... 127
8.5 Conclusion ... 128 8.6 References ... 129
9
LIST OF ABBREVIATIONS ... 133
10
LIST OF FIGURES ... 137
11
LIST OF TABLES... 141
12
SUMMARY ... 143
13
RESUMEN... 145
14
SAMENVATTING ... 147
15
ACKNOWLEDGEMENTS ... 151
16
CURRICULUM VITAE ... 153
8
17
LIST OF PUBLICATIONS ... 155
17.1 Journal articles ... 155
17.2 Conference articles and presentations ... 155
17.3 Book chapter ... 155
