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University of Groningen

Rational clinical examination of the critically ill patient

Hiemstra, Bart

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Hiemstra, B. (2019). Rational clinical examination of the critically ill patient. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Rational clinical examination

of the critically ill patient

Bart Hiemstra

Rational clinical examination

of the critically ill patient

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531658-L-bw-Hiemstra 531658-L-bw-Hiemstra 531658-L-bw-Hiemstra 531658-L-bw-Hiemstra Processed on: 5-6-2019 Processed on: 5-6-2019 Processed on: 5-6-2019

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http://books.ipskampprinting.nl/thesis/

Layout Bianca Pijl, www.pijlldesign.nl

Groningen, the Netherlands

Cover design Bianca Pijl

Printed by Ipskamp Printing

Enschede, the Netherlands

ISBN 978-94-034-1674-8 (print)

978-94-034-1673-1 (digital)

© Copyright 2019 B. Hiemstra, Groningen, the Netherlands

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author, or when appropriate, of the publishers of the publications included in this thesis.

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Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties

De openbare verdediging zal plaatsvinden op woensdag 3 juli 2019 om 11.00 uur

door

Bart Hiemstra

geboren op 2 april 1990 te Sneek

Rational clinical examination

of the critically ill patient

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Promotores

Dr. J.C.C. van der Horst Prof. dr. A.M.G.A. de Smet

Copromotor

Dr. F. Keus

Beoordelingscommissie

Prof. dr. J.C. ter Maaten Prof. dr. D. van Dijk Prof. dr. D. Gommers

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Paranimfen

Drs. R.J. Eck Dr. F.H. Heida

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7 Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9

Table of contents

General introduction and thesis outline

Clinical examination for diagnosing circulatory shock

Clinical examination, critical care ultrasonography and outcomes in the critically ill: cohort profile of the Simple Intensive Care Studies-I Statistical analysis plans for observational studies

Detailed statistical analysis plan of the Simple Intensive Care Studies-I The diagnostic accuracy of clinical examination for estimating cardiac index in critically ill patients: the Simple Intensive Care Studies-I Clinical examination for the prediction of mortality in the critically ill: the Simple Intensive Care Studies-I

Dopamine in critically ill patients with cardiac dysfunction:

a systematic review with meta-analysis and Trial Sequential Analysis Summary, discussion and future perspectives

Nederlandse samenvatting List of abbreviations List of publications About the author Dankwoord 9 17 33 51 67 99 145 173 209 223 225 227 229 231

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