University of Groningen
Towards novel biomarkers and rational nutritional interventions in Inflammatory Bowel
Disease
von Martels, Julius Zweder Hubertus
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
von Martels, J. Z. H. (2019). Towards novel biomarkers and rational nutritional interventions in
Inflammatory Bowel Disease. Rijksuniversiteit Groningen.
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Toward novel biomarkers and rational nutritional
interventions in Inflammatory Bowel Disease
STELLINGEN BEHORENDE BIJ HET PROEFSCHRIFT
door Julius von Martels
1. The adequacy and thus selection of an optimal in vitro model of the gut to assess host-microbe interactions is dependent on the research question. (This thesis) 2. In vitro models of host-microbe interactions, such as the HoxBan co-culture
system, are predictive screening tools to investigate the potential effects of specific gut bacterial species and their interactions with the intestinal epithelium in humans. (This thesis)
3. Determining serum inflammatory biomarkers as a method to assess inflammatory disease activity and to guide therapeutic decisions in IBD has a large potential, and will be used as a common practice in IBD treatment in the near future. (This
thesis)
4. Serum free thiols comprise a robust and reliable read-out of systemic oxidative stress and are promising biomarkers for disease activity in IBD. (This thesis) 5. Orally administered and urine excreted 52Cr-EDTA demonstrates that gut
inflammation is associated with an increased permeability of the gut in Crohn’s disease patients. (This thesis)
6. Crohn’s disease patients will benefit from evidence-based anti-inflammatory dietary supplements. (This thesis)
7. Despite the obvious clinical relevance of dietary intervention in Crohn’s disease, there is a disturbing lack of financial support for controlled nutritional prospective studies.
8. Today, it is still very true that ‘The best doctors in the world are Doctor Diet, Doctor Quiet and Doctor Merryman’. (Jonathan Swift, 1738)
9. All research should be published in open access journals.
10. ‘You get bad breaks from good shots; and you get good breaks from bad shots – but you have to play the ball where it lies.’ This quote from the American professional golfer Bobby Jones about the game of golf is equally applicable to (medical) scientific research.
