University of Groningen
Towards novel biomarkers and rational nutritional interventions in Inflammatory Bowel
Disease
von Martels, Julius Zweder Hubertus
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
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von Martels, J. Z. H. (2019). Towards novel biomarkers and rational nutritional interventions in Inflammatory Bowel Disease. Rijksuniversiteit Groningen.
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Towards novel biomarkers and
rational nutritional interventions in
Inflammatory Bowel Disease
The research position of drs. J.Z.H. von Martels was financially supported by the Top Institute Food and Nutrition (TiFN) in Wageningen and the Center for Development and Innovation (CDI) of the University Medical Center Groningen (UMCG).
For the financial support in the printing costs of this thesis I gratefully acknowledge the following institutions:
- Graduate School of Medical Sciences of the UMCG - University of Groningen
- DSM Nutritional products (see below for the logo)
ISBN (printed version): 978-94-6323-587-7 ISBN (electronic version): 978-94-6323-638-6
Cover design: Ilse Modder (www.ilsemodder.nl) Lay-out: Ilse Modder (www.ilsemodder.nl) Printed by: Gildeprint - Enschede
© 2019 Julius Z.H. von Martels
All rights reserved. No part of this thesis may be reprinted, reproduced, or utilized in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording of any information storage or retrieval system, without prior written permission of the author.
Towards novel biomarkers and
rational nutritional interventions in
Inflammatory Bowel Disease
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op
woensdag 5 juni 2019 om 14.30 uur
door
Julius Zweder Hubertus von Martels
geboren op 21 oktober 1987 te Groningen
Promotores Prof. dr. G. Dijkstra Prof. dr. P. de Vos Prof. dr. K.N. Faber Copromotor Dr. H.J.M. Harmsen Beoordelingscommissie Prof. dr. J.H. Kleibeuker Prof. dr. G. Bouma Prof. dr. C.Y. Ponsioen
Paranimfen
A.R. Bourgonje S.F.E. Paas
TABLE OF CONTENTS
Chapter 1 General introduction and outline of this thesis
Chapter 2 The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut
Chapter 3 A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells
Chapter 4 Increased fecal calprotectin levels in Crohn’s disease correlate with elevated serum Th1- and Th17-associated cytokines Chapter 5 A combined set of four serum inflammatory biomarkers reliably
predicts endoscopic disease activity in Inflammatory Bowel Disease
Chapter 6 Crohn’s disease in clinical remission is marked by systemic oxidative stress
Chapter 7 Assessing intestinal permeability in Crohn’s disease patients using orally administered 52Cr-EDTA
Chapter 8 Riboflavin suppresses inflammation and attenuates Crohn’s disease symptoms (RISE-UP Study)
Chapter 9 Summary, discussion and future perspectives Addendum Nederlandse samenvatting
List of Publications Author Affiliations Curriculum Vitae Dankwoord 11 23 49 69 87 123 145 167 209 222 227 229 230 231
