University of Groningen
Integration techniques for modern bioinformatics workflows
Kanterakis, Alexandros
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Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Kanterakis, A. (2018). Integration techniques for modern bioinformatics workflows. University of Groningen.
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Stellingen
1. For genetics to be able to improve healthcare, we need bioinformatics workflows that have the reliability, usability and availability of a medical procedure. (this thesis)
2. Modern workflow management systems in bioinformatics suffer from the lock-in syndrome. (this thesis)
3. Adopting open source policies is a good first step, but not the panacea to the reproducibility crisis. (this thesis)
4. The genetic coverage that can be achieved with imputation from mod-ern reference panels is enough to detect associations even for very rare variants. (this thesis)
5. Contributing to science should be conceived as editing a publicly acces-sible and community maintained book of knowledge. Crowdsourcing can accommodate this. (this thesis)
6. Deviations from standards can significantly augment the applicability
of bioinformatics methods. This is the case for the HGVS variant
processing tool: MutationInfo. (this thesis)
7. Bioinformatics workflows are sensitive and fragile stacks of complex software modules that require human effort for their maintenance and re-use.
8. ...however, by employing technologies such as virtualization, cross-platform languages, and web services we can significantly reduce this effort. (this thesis)
9. The whole is greater than the sum of its parts. (Aristotle)
Propositions belonging to the doctoral thesis ‘Integration techniques for mod-ern bioinformatics workflows’, by A. Kanterakis, 2018
