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Variable Wnt signalling activity despite clonal APC mutation throughout the tumor suggests regulation by the tumor enviroment.. Kanker wordt binnenkort een

Although both cDC subsets have the ability to take up and present exogenous antigens on MHCI, CD8α + DCs are known for their specialized and much more efficient cross-presentation

Chapter 4 Characterization of antigen-containing compartments after Fcγ receptor or C-type lectin receptor-mediated uptake in dendritic cells 75 Chapter 5 Glycan modification

Ex vivo loading of DCs with immune complexes, consisting specific antibodies complexed with tumor-associated protein antigen, have shown efficient MHCI and MHCII antigen

C57BL/6 mice that have been injected with OVA specific antibody followed by OVA antigen received OTI T cell adoptive transfer after 48 h or 1 week (Fig.. The induction

together, we show that C1q drastically affects in vivo circulating antibody-mediated antigen uptake and thereby controlling antigen presentation efficiency by splenic APC subsets to T

Strikingly, both BM-DCs as well as spDCs induced substantially more proliferation of OT-I T cells when they were pulsed with OVA-Le X compared to native.. OVA (Figure 4B,

Both unlabeled and Cy5 labeled R- Pam-peptide conjugates were able to trigger human TLR-2 and induced IL-8 production by HEK cells (Fig 2B).. The S- Pam-peptide conjugate did