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The handle http://hdl.handle.net/1887/136915 holds various files of this Leiden University dissertation.
Author: Voorneveld, P.W.
Stellingen behorend bij het proefschrift getiteld Bone Morphogenetic Protein signaling in Colorectal Cancer progression
1. Targeted therapy seems very attractive, but has some pitfalls. The
tumor-suppressive BMP pathway switching into a pro-metastatic pathway upon SMAD4 loss, is a good example of the caution that should be taken. (this thesis, chapter 3) 2. Looking for a suitable target, ROCK seems like a good option. (this thesis, chapter 3) 3. BMP induction in the stem cell compartment of mice intestines resulted in a sort of
reset. This could be used in cancer therapy. (this thesis, chapter 2)
4. Immunohistochemistry of phosphorylated protein is unreliable. It is therefore difficult to measure BMP activity in tissue (this thesis, chapter 7)
5. A statin a day, keeps the doctor away (this thesis, chapter 9 and thesis RJ Jacobs) 6. Tumor micro-environment is getting more and more attention, also as a potential
target for treatment (this thesis, chapter 5; Mueller MM. Nature reviews Cancer 2004; 4(11): 839-49.)
7. Variable Wnt signalling activity despite clonal APC mutation throughout the tumor suggests regulation by the tumor enviroment. (this thesis, chapter 4; Brabletz T. Proceedings of the National Academy of Sciences of the United States of America 2001; 98(18): 10356-61.
8. Kanker wordt binnenkort een chronische ziekte. Dit soort uitspraken komen wel eens langs in de media, en voor sommige kankersoorten klopt dit misschien, maar er zijn typen maligniteit waarbij de vooruitgang teleurstellend traag is. (SEER Cancer Statistics Review)
9. There have been times on this trip I’ve been convinced that the GPS was wrong (adapted from Chris Robb, 2016)
10. In het onderzoek (en In het leven) is het soms goed ogenschijnlijk doelloos rond te zwerven. (‘Not all who wander, are lost’ – Tolkien, 1954)
11. Onderzoek doen is leren omgaan met teleurstellingen en fouten (‘Only two sailors, in my experience, never ran aground. One never left port and the other was an
