University of Groningen
Mechanisms of glucocorticoid insensitivity in asthma
Zijlstra, Jan
DOI:
10.33612/diss.136678943
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Zijlstra, J. (2020). Mechanisms of glucocorticoid insensitivity in asthma. University of Groningen. https://doi.org/10.33612/diss.136678943
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Mechanisms of glucocorticoid
insensitivity in asthma
© Geert Jan Zijlstra 2020
Cover: Impression: soleil levant van Claude Monet layout and print: Guus Gijben | Proefschrift-aio.nl
Mechanisms of glucocorticoid
insensitivity in asthma
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 18 november 2020 om 11.00 uur
door Geert Jan Zijlstra geboren op 18 mei 1986
Promotores
Prof. dr. H.I. Heijink
Prof. dr. A.J.M. van Oosterhout Copromotor
Dr. N.H.T. ten Hacken Beoordelingscommissie Prof. dr. H.A.M. Kerstjens Prof. dr. F.J. Dekker Prof. dr. L. Koenderman
Paranimfen Drs. M.J. Zijlstra Drs. H.W. Zijlstra
Table of Contents
Chapter 1. General introduction
Chapter 2. Characterization of glucocorticosteroid response in mild-
to-moderate asthma Manuscript in preparation
Chapter 3. Short Communication: Smoking and inhaled corticosteroid
use are independently associated with higher histone deacetylase-2 expression in bronchial epithelial cells in asthma
Manuscript in preparation
Chapter 4. Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells.
European Respiratory Journal (2012); 39; 439-445 Supplement to chapter 4
Chapter 5. Glucocorticoids induce the production of the
chemoattractant CCL20 in airway epithelium European Respiratory Journal (2014); 44; 361-370
Supplement to chapter 5
Chapter 6. Cigarette smoke-induced necroptosis and DAMP release
trigger neutrophilic airway inflammation in mice American Journal of Physiology - Lung Cell and Molecular
Physiology (2016); 310; L377–L386
Chapter 7. Summary, General discussion, Future perspectives
Chapter 8. Nederlandse samenvatting
Chapter 9. Dankwoord 9 21 41 49 65 67 83 87 109 123 127
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