University of Groningen Novel preclinical models, therapies and biomarkers for testicular cancer Rosas Plaza, Fernanda

University of Groningen

Novel preclinical models, therapies and biomarkers for testicular cancer

Rosas Plaza, Fernanda

DOI:

10.33612/diss.119056452

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Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Rosas Plaza, F. (2020). Novel preclinical models, therapies and biomarkers for testicular cancer. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.119056452

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NOVEL PRECLINICAL MODELS,

THERAPIES AND BIOMARKERS

FOR TESTICULAR CANCER

PhD thesis

ISBN: 978-94-034-2500-9

ISBN (electronic version): 978-94-034-2499-6 Cover and layer-out design: Merit González Printing of this thesis was supported by: - Stichting Werkgroep Interne Oncologie - The Graduate School of Medical Sciences - University Library

© Copyright 2020, F. X. Rosas Plaza

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form without permission by the author.

to obtain the degree of PhD at the University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga and in accordance with

the decision by the College of Deans. This thesis will be defended in public on

Monday 9 March 2020 at 14:30

by

born on 31 May 1987 in Mexico City, Mexico

PhD thesis

Fernanda Ximena Rosas Plaza

Novel preclinical models,

therapies and biomarkers

Supervisors

Prof. S. de Jong Prof. J. A. Gietema

Prof. M. A. T. M. van Vugt

Assessment committee

Prof. W.N. Keith Prof. A. van den Berg Prof. F.A.E. Kruyt

Table of contents

General Introduction and outline of thesis 7 miR-371a-3p, miR-373-3p and miR-367-3p as serum biomarkers in metastatic testicular germ cell cancers before, during and after chemotherapy 29

Cells, 2019, 8, 1221

Dual mTORC1/2 inhibition sensitizes testicular cancer models to cisplatin treatment 55

Molecular Cancer Therapeutics, 2020, 19: 590-601

Establishment and characterization of testicular cancer patient-derived xenograft models for preclinical

evaluation of novel therapeutic strategies 81

In preparation

AFP levels do not predict response to cisplatin in

testicular cancer patient-derived xenograft models 105 Summary, general discussion and future perspectives 115 Nederlandse samenvatting (Summary in Dutch) 129 Acknowledgements 135 List of publications 138