University of Groningen
Gene-environment interactions on the course of Attention-Deficit/Hyperactivity Disorder
(ADHD) symptoms
Brinksma, Djûke Maaike
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Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Brinksma, D. M. (2018). Gene-environment interactions on the course of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms: From early into late adolescence. Rijksuniversiteit Groningen.
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Gene-environment interactions on the course of
Attention-Deficit/Hyperactivity Disorder symptoms
From early into late adolescence
This research is part of the TRacking Adolescents’ Individual Lives Survey (TRAILS). Participating centers of TRAILS include various departments of the University Medical Center and University of Groningen, the Erasmus University Medical Center Rotterdam, the University of Utrecht, the Radboud Medical Center Nijmegen, and the Parnassia Bavo group, all in the Netherlands. TRAILS has been financially supported by various grants from the Netherlands Organization for Scientific Research (NWO), ZonMW, GBMaGW, the Dutch Ministry of Justice, the European Science Foundation, BBMRI-NL, the participat-ing universities, and Accare Center for Child and Adolescent Psychiatry. We are grateful to all adolescents, their parents, and teachers who participated in this research, and to everyone who worked on this project and made it possible.
ISBN (print): 978-94-034-1062-3
ISBN (digital): 978-94-034-1061-6
Cover design: Juliëtte Gerards
Lay out: Everdina Meilink, XML2PUBLISH Printing & published: Gildeprint, Enschede, The Netherlands. © Djûke M. Brinksma, 2018
All rights reserved. No part of this publication may be reproduced, distributed, or trans-mitted in any form or by any means without the prior written permission of the author.
Gene-environment interactions on
the course of
Attention-Deficit/Hyperactivity Disorder
(ADHD) symptoms
From early into late adolescence
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 7 november 2018 om 16.15 uur
door
Djûke Maaike Brinksma geboren op 12 februari 1990
te Den Ham
Gene-environment interactions on the course of
Attention-Deficit/Hyperactivity Disorder symptoms
From early into late adolescence
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 7 november 2018 om 16.15 uur
door
Djûke Maaike Brinksma
geboren op 12 februari 1990 te Den Ham
Promotores Prof. dr. P.J. Hoekstra Prof. dr. J.K. Buitelaar Copromotor Dr. A. Dietrich Beoordelingscommissie Prof. dr. B. Franke Prof. dr. S.A. Reijneveld Prof. dr. R.R.J.M. Vermeiren
INDEX
1 | General introduction 7
2 | Age-dependent role of pre- and perinatal factors in interaction with genes
on ADHD symptoms across adolescence
27
3 | Parental rejection in early adolescence predicts a persistent ADHD
symptom trajectory across adolescence
43
4 | ADHD symptoms in middle adolescence predict exposure to person-related
life stressors in late adolescence in 5-HTTLPR S-allele homozygotes
67
5 | ADHD symptoms across adolescence: the role of the family and school
climate and the DRD4 and 5-HTTLPR genotype
87
6 | General summary and discussion 113
* | Supplementary information 127
Nederlandse samenvatting 138
Dankwoord 146
Recent dissertations TRAILS 150
Curriculum vitae 156
