A study into genes encoding longevity in humans
Kuningas, M.
Citation
Kuningas, M. (2007, December 4). A study into genes encoding longevity in
humans. Retrieved from https://hdl.handle.net/1887/12474
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral
thesis in the Institutional Repository of the University
of Leiden
Downloaded from: https://hdl.handle.net/1887/12474
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A Study into Genes Encoding
Longevity in Humans
Maris Kuningas
A Study into Genes Encoding Longevity in Humans Kuningas, Maris
Thesis, Leiden University, The Netherlands Cover design: Maris Kuningas
Printed by Printpartners Ipskamp Grafische Specialisten, Enschede, The Netherlands ISBN: 978-90-9022430-5
Copyright © Maris Kuningas, 2007
A Study into Genes Encoding Longevity in Humans
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 4 december 2007
klokke 15.00 uur door
Maris Kuningas geboren te Kuressaare (Estland)
in 1979
Promotiecomissie
Promotores: Prof. dr. R.G.J. Westendorp Prof. dr. P.E. Slagboom
Copromotor: Dr. ir. D. van Heemst
Referent: Prof. dr. A. Metspalu (Tartu University, Estonia) Overige leden: Prof. dr. E.R. de Kloet
Prof. dr. R.R. Frants
This work was supported by an Innovative Orientated Research (IOP) grant from the Dutch Ministry of Economic Affairs (grant number IGE010114), by the Netherlands Genomics Initia- tive/Netherlands Organization for Scientific Research (NWO) (grant number 911-03-016) and by the Centre for Medical Systems Biology (CMSB), which is a centre of excellence approved by the NWO. Maris Kuningas was supported by a Marie Curie Fellowship of the European Com- munity program EUROGENDIS “The Genetic Basis of Disease” (contract number QLGA- GH-00-60005-59).
Printing of this thesis was financially supported by Unilever and Numico B.V.
Contents
CHAPTER 1 General Introduction ... 7
CHAPTER 2 Haplotypes in the Human FOXO1a and FOXO3a Genes; Impact on Disease and Mortality at Old Age ... 19
European Journal of Human Genetics (2007) 15, 294–301 CHAPTER 3 The Liver X Receptor Alpha Associates with Human Lifespan ... 35
The Journals of Gerontolog y Series A: Biological Sciences and Medical Sciences (2007) 62A, 343–349 CHAPTER 4 VDR Gene Variants Associate with Cognitive Function and Depressive Symptoms in Old Age ... 51
Neurobiolog y of Ageing (in press) CHAPTER 5 SIRT1 Gene, Age-Related Diseases and Mortality. The Leiden 85-Plus Study ...67
The Journals of Gerontolog y Series A: Biological Sciences and Medical Sciences (2007) 62, 960-965 CHAPTER 6 Mental Performance in Old Age Dependent on Cortisol and Genetic Variance in the Mineralocorticoid- and Glucocorticoid Receptors .... 83
Neuropsychopharmacolog y (2007) 32, 1295–1301 CHAPTER 7 Genetic Variants in the Glucocorticoid Receptor Gene (NR3C1) and Cardiovascular Disease Risk. The Leiden 85-Plus Study ...97
Biogerontolog y (2006) 7, 231-238 CHAPTER 8 Impact of Genetic Variations in the WRN Gene on Age Related Pathologies and Mortality ...111
Mechanisms of Ageing and Development (2006) 127, 307-313 CHAPTER 9 Genes Encoding Longevity; from Model Organisms to Man ...127
Submitted for publication CHAPTER 10 Samenvatting/Summary in Dutch ... 149
Acknowledgements ...153
List of publications ...154
Curriculum vitae ...155
