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University of Groningen

Epidemiology of metabolic health

Slagter, Sandra Nicole

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Slagter, S. N. (2017). Epidemiology of metabolic health: Lifestyle determinants and health-related quality of

life. Rijksuniversiteit Groningen.

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EpidEmiology of mEtabolic hEalth

Lifestyle determinants and health-related quality of life

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Epidemiology of metabolic health

Lifestyle determinants and health-related quality of life Thesis, University of Groningen, the Netherlands

cover design: Mark van Wijk - markvanwijk.net

lay-out: Ridderprint BV - www.ridderprint.nl

printing: Ridderprint BV - www.ridderprint.nl

iSbN: 978-90-367-9383-4 (printed) 978-90-367-9382-7 (eBook)

copyright © Sandra N. Slagter, Groningen 2016.

All rights reserved. No parts of this thesis may be reproduced or transmitted in any form or by any means, without prior permission of the author.

This work was supported by the BioSHaRE-EU project (Biobank Standardisation and Harmonisation for Research Excellence in the European Union) under grant agreement n°261433, receiving funds from the National Consortium for Healthy Ageing, and from the European Union’s Seventh Framework Program (FP7/2007-2013).

The LifeLines Cohort Study is supported by the Netherlands Organization of Scientific Research NWO (grant 175.010.2007.006), the Ministry of Economic Affairs, the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the Northern Netherlands Collaboration of Provinces (SNN), the Province of Groningen, University Medical Center Groningen, the University of Groningen, Dutch Kidney Foundation and Dutch Diabetes Research Foundation.

Financial support for printing of this thesis was kindly provided by: The Endocrinology Fund (as part of the Ubbo Emmius Fund), Graduate School of Medical Sciences/University Medical Center Groningen, Univer-sity of Groningen and Novo Nordisk BV.

Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowl-edged.

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EpidEmiology of mEtabolic hEalth

Lifestyle determinants and health-related quality of life

proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

woensdag 11 januari 2017 om 12.45 uur

door

Sandra Nicole Slagter

geboren op 21 augustus 1990

te Assen

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promotor

Prof. dr. B.H.R. Wolffenbuttel

copromotores

Dr. J.V. van Vliet-Ostaptchouk

Dr. M.M. van der Klauw

beoordelingscommissie

Prof. dr. R. Sanderman

Prof. dr. O.H. Franco

Prof. dr. L. van Gaal

(6)
(7)

paranimfen

R.A. Slagter

J.M.J. Noble

(8)

coNtENtS

chapter 1

General introduction

9

chapter 2

The prevalence of metabolically healthy obesity in Europe:

a collaborative analysis of ten large cohort studies.

BMC Endocrine Disorders 2014, 14:9

21

chapter 3

Associations between smoking, components of the

metabolic syndrome and lipoprotein particle size.

BMC Medicine 2013 11:195

47

chapter 4

Combined effects of smoking and alcohol on metabolic

syndrome: The LifeLines Cohort Study.

PLoS ONE 2014, 9(4):e96406

75

chapter 5

Dietary patterns and physical activity in the (un) healthy

obese: The LifeLines cohort study.

In preparation

101

chapter 6

Health-related quality of life in relation to obesity grade,

type 2 diabetes, metabolic syndrome and inflammation.

PLoS ONE 2015, 10(10):e0140599

135

chapter 7

Sex, BMI and age differences in metabolic syndrome:

updated prevalence estimates in the Netherlands.

In preparation

161

chapter 8

Summary and general discussion

185

Nederlandse samenvatting

211

Acknowledgements / Dankwoord

217

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