The handle http://hdl.handle.net/1887/137728 holds various files of this Leiden University dissertation.
Author: Kwast, R.V.C.T. van der
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Curriculum Vitae
Reginald Victor Carl Theodoor van der Kwast was born on the October nd, in Manama, Bahrain. During his youth, he lived in many different countries: Bahrain, Singapore, Saudi Arabia, the Netherlands and the United States. In , he graduated from the American School of the Hague and obtained a Full International Baccalaureate Diploma as well as an extracurricular certificate for Higher Level Chemistry. That same year, he started studying Biopharmaceutical Sciences at the Leiden University. During his studies he became especially interested in molecular biology and cardiovascular research. As a result, Reginald sought out a master’s internship at the Vascular Surgery department of the Leiden University Medical Center. During this internship, he studied the role of q microRNAs in vascular remodeling under supervision of prof. dr. Quax and dr. Nossent. Afterward he secured an internship at the Division of Cardiology at the University of Washington under supervision of dr. Dichek. In this -month period he explored different strategies to increase expression of a therapeutic transgene to treat cardiovascular disease, resulting in his first co-authored publication.
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List of Publications
van der Kwast RV, Parma L, van der Bent ML, van Ingen E, Baganha F, Peters HA, Goossens EA, Simons KH, Palmen M, de Vries MR, Quax PH, Nossent AY
Adenosine-to-Inosine editing of vasoactive microRNAs alters their targetome and function in ischemia
Molecular Therapy – Nucleic Acids. July; in press. van der Kwast RV, Woudenberg T, Quax PH, Nossent AY.
MicroRNA- and its ’-IsomiR have distinct targets and functions and are differentially regulated in the vasculature.
Molecular Therapy. Jan ; ( ): -van der Kwast RV, Quax PH, Nossent AY.
An emerging role for isomiRs and the microRNA epitranscriptome in neovascularization.
Cells. Dec ; ( )
Håkansson KE, Goossens EA, Trompet S, van Ingen E, de Vries MR, van der Kwast RV, Ripa RS, Kastrup J, Hohensinner PJ, Kaun C, Wojta J, Böhringer S, Cessie S, Jukema JW, Quax PH, Nossent AY.
Genetic associations and regulation of expression indicate an independent role for q snoRNAs in Human Cardiovascular Disease.
Cardiovascular Research. Aug ; ( ):
-van der Kwast RV, -van Ingen E, Parma L, Peters HA, Quax PH, Nossent AY.
Adenosine-to-Inosine Editing of MicroRNA- b Alters Target Gene Selection After Ischemia and Promotes Neovascularization.
Circulation Research. Feb ; ( ):
-Dronadula N, Wacker BK, van der Kwast RV, Zhang J, Dichek DA.
Stable In Vivo Transgene Expression in Endothelial Cells with Helper-Dependent Adenovirus: Roles of Promoter and Interleukin- .
Human Gene Therapy. Mar; ( ): - .
van der Kwast RV, van den Homberg DA, Quax PH, Nossent AY.
Hypoxia increases the expression and N- -adenosine methylation of vasoactive microRNAs in fibroblasts
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Acknowledgements
I would like to thank everybody who contributed to the realization of this thesis and everyone who supported me during this period.
I am especially grateful to my promotor Prof. Paul Quax and my co-promotor Dr. Yaël Nossent.
Dear Paul, thank you for your genuinely caring supervision and support. I have learned a lot from your publication-oriented guidance, without it I would not be finished yet.
Dear Yaël, you deserve special thanks since your empowering style of supervising and enthusiasm have shaped me as a scientist. I hope to be as efficient and inspiring as you are one day.
I am also very grateful to Erna and my roommates at C : Karin, Leontien, Valerie and Fab. You were there for me during the good times and the tough times … and all the coffee breaks in between. Thanks for the support and all the fun we had.
I would like to thank all the other members of the Quax group through the years: Margreet, Eva, Eveline, Licheng, Sabine, Kjell and Alwin, for contributing to this great work environment. Furthermore, I would like to thank my students, Tessel, Daphne, Merel, Jort, Eliis, Tamar and Anton for their invaluable help.
