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Bouncing back : trauma and the HPA-axis in healthy adults

Klaassens, E.R.

Citation

Klaassens, E. R. (2010, November 30). Bouncing back : trauma and the HPA-axis in healthy adults. Retrieved from https://hdl.handle.net/1887/16190

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/16190

Note: To cite this publication please use the final published version (if

applicable).

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Bouncing Back

Trauma and the HPA-axis in Healthy Adults

Ellen Renée Klaassens

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Bouncing Back - Trauma and the HPA-axis in Healthy Adults

© 2010 E.R. Klaassens, Alphen aan den Rijn, the Netherlands ISBN 978-90-6464-424-5

Cover design by Willem Klaassens

Cover photo by Hidde Goinga (www.hiddegoinga.com)

Sculpture on the cover: ‘La Ville détruite’ by Ossip Zadkine © Printed by GVO drukkers & vormgevers B.V. | Ponsen & Looijen

The printing costs of this dissertation were provided by Riagg Rijnmond and A. Japenga-Stijnman, which is gratefully acknowledged.

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Bouncing Back

Trauma and the HPA-axis in Healthy Adults

Proefschrift

ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof.Mr. P.F. van der Heijden,

volgens besluit van College voor Promoties ter verdediging op dinsdag 30 november 2010

klokke 16.15 uur

door

Ellen Renée Klaassens geboren te Utrecht

in 1962

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Promotiecommissie:

Promotor: Prof.dr. F.G. Zitman Co-promotoren: dr. E.J. Giltay

dr. T. van Veen

Overige leden: Prof.dr. E.R. de Kloet

Prof.dr. Ph. Spinhoven

Prof.dr. W.J.G. Hoogendijk (Vrije Universiteit Amsterdam)

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In liefdevolle herinnering aan

Benthe (1989-2000)

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Contents

Chapter 1

Introduction and outline of the studies

Chapter 2

Effects of childhood trauma on HPA-axis reactivity in women free of lifetime psychopathology

Chapter 3

Mental health of Dutch Peacekeeping Veterans 10-25 years after deployment

Chapter 4

Trauma exposure and HPA-axis functioning in mentally healthy Dutch Peacekeeping Veterans, 10-25 years after deployment

Chapter 5

Trauma exposure in relation to basal salivary cortisol and the hormone response to the Dex/CRH test in male railway employees without lifetime psychopathology

Chapter 6

Adulthood trauma and cortisol in healthy subjects and PTSD patients: a meta-analysis

Chapter 7

Summary, Discussion and Future perspectives

Nederlandse Samenvatting Dankwoord

Curriculum Vitae Publications Abbreviations

12

40

58

72

90

108

134

156 170 175 179 183

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