University of Groningen
Paving the way for pulmonary influenza vaccines
Tomar, Jasmine
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Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Tomar, J. (2018). Paving the way for pulmonary influenza vaccines: Exploring formulations, models and
site of deposition. University of Groningen.
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PROPOSITIONS
Belonging to the PhD thesis
Paving the Way for Pulmonary Influenza Vaccines
Exploring formulations, models and site of deposition
By
Jasmine Tomar
1) Dry influenza vaccines administered via non-parenteral patient friendly dosage forms such as microneedles for administration via the skin, tablets for oral and powders for pulmonary administration are suitable and effective alternatives to parenteral influenza vaccines (Chapter 2 of this thesis).
2) Site of deposition within the respiratory tract holds minor relevance for inhaled vaccines against air-borne infectious diseases such as influenza but deep lung deposition is crucial for inhaled vaccines against non air-borne infectious diseases such as hepatitis B (Chapter 4 of this thesis).
3) Administration of effective influenza vaccine formulations to the lungs of relevant animal models with suitable delivery devices is a step towards clinical application (this thesis). 4) Crystalline delta inulin is a potent mucosal adjuvant (Chapter 5 of this thesis).
5) Passive inhalation is a feasible and effective method of mass vaccination for chickens that has the potential to be translated to field settings and consequently restrict the dissemination of avian influenza (Chapter 6 of this thesis).
6) A PhD thesis involves a long and persistent behavioural output in the absence of immediate reinforcement (James Coyne, ‘’Beating the dissertation blues’’ talk).
7) Hard work combined with a pinch of smartness is the key to success in the 21st century. 8) Success is not final, failure is not fatal: it is the courage to continue that counts (Winston
S. Churchill).
9) The flavour of a good food not only depends upon the right spices but also on the feelings with which the food is cooked.
10) The most challenging yet rewarding work is being a mother, with your child as the center of your universe.
