University of Groningen
Paving the way for pulmonary influenza vaccines
Tomar, Jasmine
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Publication date: 2018
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Tomar, J. (2018). Paving the way for pulmonary influenza vaccines: Exploring formulations, models and site of deposition. University of Groningen.
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Paving the Way for Pulmonary
Influenza Vaccines
Exploring formulations, models and site of deposition
Cover design
Tushar Tomar and Pharma Pulse
Printing
PrintSupport4U
Layout
Pharma Pulse (www.pharmapulse.net)
Thesis printing was financially supported by
The research presented in this thesis was financially supported by
European Union Seventh Framework Program 19 (FP7/2007-2013) and Universal Influenza Vaccines Secured (UNISEC) consortium under grant agreement no. 602012. It was also supported by the Dutch Ministry of Economic Affairs (WOT-01-003-067; KB-21-006-012).
Dissertation of University of Groningen, Groningen, The Netherlands
ISBN : 978-94-034-1168-2 (printed) ISBN: 978-94-034-1167-5 (digital) © Jasmine Tomar, Groningen, 2018 email ID: tomarjasmine@gmail.com
All rights reserved. No parts of this thesis may be reproduced or transmitted in any form or by any means, without written permission from the author.
Graduate School of Science and Engineering (GSSE)
Innovative Research of America
PerkinElmer Southern Biotech
ChipSoft Abcam Greiner bio-one
Paving the Way for
Pulmonary Influenza Vaccines
Exploring formulations, models and site of deposition
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Friday 7 December 2018 at 14.30 hours
by
born on 17 August 1989 in Kaithal, India
Supervisors
Prof. dr. H.W. Frijlink Prof. dr. A.L.W. Huckriede
Co-supervisor
Dr. W.L.J. Hinrichs
Assessment Committee
Prof. dr. G.F. Kersten Prof. dr. C.A.H.H. Daemen Prof. dr. D. Christensen
Paranymphs
Gerian Prins Atul Vatts
Chapter 1 Introduction and outline of this thesis
Chapter 2 Dry influenza vaccines: towards a stable, effective and convenient
alternative to conventional parenteral influenza vaccination
Chapter 3 Pulmonary delivery of influenza vaccine formulations in cotton rats:
site of deposition plays a minor role in the protective efficacy against clinical isolate of H1N1pdm virus
Chapter 4 Pulmonary immunization: deposition site is of minor relevance for
influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination
Chapter 5 Advax augments B and T cell responses upon influenza vaccination
via the respiratory tract and completely protects mice against lethal influenza virus challenge
Chapter 6 Passive inhalation of dry powder influenza vaccine formulations
completely protects chickens against H5N1 lethal viral challenge
Chapter 7 Summary, concluding remarks, and perspectives Appendices
III Nederlandse Samenvatting
III Curriculum vitae with list of publications
III Acknowledgements
