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University of Groningen

Health of offspring of subfertile couples

Kuiper, Derk

DOI:

10.33612/diss.92269971

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Kuiper, D. (2019). Health of offspring of subfertile couples. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.92269971

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Health of offspring of subfertile couples

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Health of off spring of subferti le

couples

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnifi cus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoti es.

De openbare verdediging zal plaatsvinden op maandag 16 september 2019 om 12.45 uur

door

Derk Kuiper

geboren op 30 januari 1992 te Groningen

The studies in this thesis have been carried out with fi nancial support from the University of Groningen, the University Medical Center Groningen (grant number 754510), Research Insti tute SHARE, the Netherlands Organizati on for Health Research and Development (ZonMw, grant number 945-03-013) and the Cornelia Foundati on.

Printi ng of this thesis was fi nancially supported by: the University of Groningen, University Medical Center Groningen and Research Insti tute SHARE.

ISBN printed version: 978-94-034-1834-6 ISBN electronic version: 978-94-034-1833-9

Cover design: Wytze Hoogslag (www.wytzehoogslag.nl)

Tupesetti ng, layout and printi ng: Ridderprint | www.ridderprint.nl © Copyright 2019, D. Kuiper, the Netherlands.

All rights reserved. No part of this thesis may be reproduced or transmitt ed in any form or by any means, electronic or mechanical, including photocopying, recording or any informati on storage and retrieval system, without prior writt en permission of the author or, when appropriate, of the publishers of the publicati ons.

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Paranimfen Eelke Nikkels Jorien Seggers Promotores Prof. dr. M. Hadders-Algra Prof. dr. A. Hoek Prof. dr. M.J. Heineman Beoordelingscommissie Prof. dr. D.D.M. Braat Prof. dr. R.J.B.J. Gemke Prof. dr. S.A. Scherjon

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Table of Contents

Chapter 1 Introduction

Chapter 2 Neurodevelopmental and cardiometabolic outcome in 4-year-old twins and singletons born after IVF

Chapter 3 Asthma and the use of asthma medication in 4-year-old offspring of subfertile couples

Chapter 4 Asthma in 9-year-old children of subfertile couples is not associated with in vitro fertilization procedures

Chapter 5 In Vitro Fertilization is associated with refractive errors in 11-year-old offspring

Chapter 6 Cardiovascular health of 9-year-old IVF offspring: No association with ovarian hyperstimulation and the in vitro procedure Chapter 7 Parental subfertility is associated with higher blood pressure in

offspring

Chapter 8 Developmental outcome of 9-year-old children born after PGS: Follow-up of a randomized trial

Chapter 9 Discussion Chapter 10 Summary

Chapter 11 Nederlandse samenvatting Appendices Acknowledgments

About the author List of publications Research Institute Share

9 49 67 75 91 99 117 125 145 161 167 174 177 178 179

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