University of Groningen
The composition and dynamic nature of the N-linked glycoprofile of bovine milk serum and its
individual proteins
Valk-Weeber, Rivca
DOI:
10.33612/diss.134363958
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Valk-Weeber, R. (2020). The composition and dynamic nature of the N-linked glycoprofile of bovine milk serum and its individual proteins: A structural and functional analysis. University of Groningen.
https://doi.org/10.33612/diss.134363958
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The composition and dynamic
nature of the N-linked glycoprofile
of bovine milk serum and its
individual proteins
A structural and functional analysis
Cover design: RivVin
Printed by: Ipskamp Printing, Enschede
The work described in this thesis was carried out in the Microbial Physiology Research group which is part of the Groningen Biomolecular Sciences and Biotechnology institute (GBB) of the University of Groningen, the Netherlands. This research was financially supported by FrieslandCampina, the University of Groningen/Campus Fryslân, and the University of Groningen.
The composition and dynamic nature
of the N-linked glycoprofile of bovine milk serum
and its individual proteins
A structural and functional analysis
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op Vrijdag 9 oktober 2020 om 12:45 uur
door
Rivca Leonie Weeber
geboren op 30 mei 1984 te Stadskanaal
Promotores Prof. dr. L. Dijkhuizen Prof. dr. P. de Vos Copromotor Dr. S.S. van Leeuwen Beoordelingscommissie
Prof. dr. M. Wuhrer
Prof. dr. N.C. van de Merbel
Dr. ir. K.A. Hettinga
Chapter 1...
Introduction
Chapter 2...
Dynamic temporal variations in bovine lactoferrin glycan structures
Chapter 3...
Large-scale quantitative isolation of pure protein N-linked glycans
Chapter 4...
Dietary N-glycans from bovine lactoferrin and TLR modulation
Chapter 5...
Inhibitory effects of dietary N-glycans from bovine lactoferrin on Toll-like receptor 8; comparing efficacy with chloroquine
Chapter 6...
In depth analysis of the contribution of specific glycoproteins to the overall bovine whey N-linked glycoprofile
Chapter 7...
Rapid quantitative analysis of bovine whey glycoprotein composition using the overall N-linked whey glycoprofile
Chapter 8...
Variations in N-linked glycosylation of GlyCAM-1 whey protein: Inter-cow differences and dietary effects
Chapter 9...
Summary and Discussion
References... Nederlandse samenvatting... Dankwoord... Publicaties... 9 63 103 131 153 173 203 231 257 273 311 327 335
