Citation
Rensen, E. L. J. van. (2006, May 11). Airway inflammation in asthma : from concept to the
clinic. Retrieved from https://hdl.handle.net/1887/4383
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from:
https://hdl.handle.net/1887/4383
Airway inflammation in asthma
F rom c onc e p t to the c linic
Airway inflammation in asthma
From concept to the clinic
Proefschrift
ter verkrijging van
de graad van D octor aan de U niversiteit Leiden, op gezag van de Rector M agnificu s D r. D .D . Breim er,
hoogleraar in de facu lteit der W isku nde en Natu u rw etenschap p en en die der Geneesku nde,
volgens beslu it van het C ollege voor Prom oties te verdedigen op donderdag 1 1 m ei 2006 ,
klokke 1 4 :1 5 u u r
door
E liz a b eth L .J . v a n R en sen
Promotores: Prof. dr. P.J. Sterk Prof. dr. K .F . Rabe
Referent: Prof. dr. K .F . Chung ( National H eart and Lung Institute, UK )
O verige leden: Prof. dr. B.N. Lambrecht ( Erasmus MC, Rotterdam) Dr. H .K . Reddel ( University of Sydney, A ustralia) Prof. dr. P.S. H iemstra
Contents
Chapter 1 General introduction and aims of the studies 6 Chapter 2 Evidence for systemic rather than pulmonary effects of 30
interleukin-5 administration in asthma
Chapter 3 Effect of inhaled steroids on airway hyperresponsiveness, sputum 46 eosinophils, and ex haled nitric ox ide levels in patients with asthma
Chapter 4 Assessment of microvascular leakage via sputum induction: 62 the role of substance P and neurokinin A in patients with asthma
Chapter 5 Bronchial CD8 cell infiltrate and lung function decline in asthma 76 Chapter 6 Asthma guidelines: towards evidence-based application of peak 90
flow
Chapter 7 Anti-IgE-induced reduction in airway responses to inhaled allergen 102 is paralleled by decreased eosinophilia in bronchial biopsies and
sputum in patients with asthma
Chapter 8 Summary and general discussion 118
Chapter 9 Dutch summary; Nederlandse samenvatting 130
Acknowledgement 143
Curriculum Vitae 145
