Citation
Ackaert, O. (2010, April 28). Transdermal iontophoresis of dopaminergic (pro) drugs : from formulation to in vivo application. Retrieved from https://hdl.handle.net/1887/15336
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Transdermal iontophoresis of dopaminergic (pro)drugs:
From formulation to in vivo application
Oliver Ackaert
Transdermal iontophoresis of dopaminergic (pro)drugs:
From formulation to in vivo application Oliver Ackaert
PhD thesis with summary in Dutch April 2010
©2010 Oliver Ackaert. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without written permission of the author.
Printed by Wöhrmann Print Service (Zutphen, The Netherlands)
Transdermal iontophoresis of dopaminergic (pro)drugs:
From formulation to in vivo application
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College van Promoties
te verdedigen op woensdag 28 april 2010 klokke 13.45 uur
door
Oliver Ackaert
geboren te Turnhout, België
in 1981
Overige leden: Prof. Dr. A.P. IJzerman Prof. Dr. J.J. van Hilten Prof. Dr. T. Hankemeier
Prof. Dr. R.H. Guy (University of Bath)
The investigations described in this thesis were performed at the Division of Drug Delivery Technology of the Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands. The studies were financed by the Dutch Technology Foundation (STW LKG6507)
The publication of this thesis was financially supported by the Dutch Technology Foundation and the Leiden/Amsterdam Center for Drug Research
Table of contents
Chapter 1 Symptomatic treatment of Parkinson’s disease:
role of transdermal iontophoresis of dopamine agonists 1
Chapter 2 Objective and outline of the thesis 31 Part I-Optimizing the in vitro transdermal iontophoretic delivery of dopaminergic drugs Chapter 3 Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro 41
Chapter 4 Comparing different salt forms of rotigotine to improve transdermal iontophoretic delivery 63 Chapter 5 Transdermal iontophoresis of a novel series of dopamine agonists: physicochemical considerations 85 Part II-In vivo assessment of controlling the iontophoretic delivery of (S)-5-OH-DPAT Chapter 6 Controlling the pharmacokinetics and the pharmacodynamic effect of (S)-5-OH-DPAT with transdermal iontophoresis 115
Part III-Transdermal iontophoretic delivery of ester prodrugs of 5-OH-DPAT: from synthesis to in vivo studies Chapter 7 Controlling the pharmacokinetics and the pharmacodynamic effect of (S)-5-OH-DPAT with transdermal iontophoresis 149
Chapter 8 Summary, conclusions and perspectives 181
Appendix Samenvatting 203
List of abbreviations 215
List of publications 219
Curriculum Vitae 221
Nawoord 223
