Imaging the preterm infant's brain
Curriculum Vitae
Curriculum Vitae
Lara Maria Leijser
Geboren op 17 oktober 1978 te Goirle, Nederland
1991-1997
V.W.O., Koning Willem II College, Tilburg
1997-2003
Studie Biomedische Wetenschappen, Universiteit Leiden 2001-2002
Stage afdeling Radiologie, Leids Universitair Medisch Centrum (Dr. L. Liauw, Prof. Dr.
M.A. van Buchem) 2002-2003
Stage en scriptie afdeling Kindergeneeskunde, divisie Neonatologie, Leids Universitair Medisch Centrum (Dr. Ir. G.T.M. Wagenaar, Prof. Dr. F.J. Walther)
1999-2004
Studie Geneeskunde, Universiteit Leiden 2003-2004
Co-schappen, Leids Universitair Medisch Centrum (cum laude)
2001-2006
Wetenschappelijk onderzoek (extra-curriculair) 2001
Afdeling Neurologie, Leids Universitair Medisch Centrum (Dr. L.A.E.M. Laan) 2001-2006
Afdeling Kindergeneeskunde, divisie Neonatologie, Leids Universitair Medisch Centrum (Dr. G. van Wezel-Meijler)
Curriculum Vitae
328
2005-2006
Clinical Research Fellow, Department of Paediatrics and Neonatal Medicine, Hammersmith Hospital, Londen, Engeland (Dr. F.M. Cowan, Prof. Dr. M.A. Rutherford)
Sinds 2006
Promotie-onderzoek (ZonMw-Agiko), afdeling Kindergeneeskunde, divisie Neo- natologie, Leids Universitair Medisch Centrum. Titel: ‘Imaging the preterm infant’s brain’
(Prof. Dr. F.J. Walther, Dr. G. van Wezel-Meijler)
Sinds 2009
Opleiding Kindergeneeskunde
Juliana Kinderziekenhuis, HagaZiekenhuis, Den Haag (Dr. F. Brus) Leids Universitair Medisch Centrum, Leiden (Drs. R.N. Sukhai)
List of publications
List of publications
van Wezel-Meijler G, Steggerda SJ, Leijser LM. Cranial ultrasonography in neonates: its role and limitations. Semin Perinatol 2010, in press. Review
Leijser LM, Steggerda SJ, de Bruïne FT, van Zuijlen A, van Steenis A, Walther FJ, van Wezel-Meijler G. Lenticulostriate vasculopathy in very preterm infants. Arch Dis Child Fetal Neonatal Ed 2009 May 19 [Epub ahead of print]
van Wezel-Meijler G, Leijser LM, de Bruïne FT, Steggerda SJ, van der Grond J, Walther FJ.
Magnetic resonance imaging of the brain in newborn infants: practical aspects. Early Hum Dev 2009; 85(2): 85-92. Review
Steggerda SJ, Leijser LM, Walther FJ, van Wezel-Meijler G. Neonatal cranial ultrasonography: how to optimize its performance. Early Hum Dev 2009; 85(2): 93-99.
Review
Leijser LM, de Bruïne FT, Steggerda SJ, van der Grond J, Walther FJ, van Wezel-Meijler G. Brain imaging findings in very preterm infants throughout the neonatal period: Part I. Incidences and evolution of lesions, comparison between ultrasound and MRI. Early Hum Dev 2009; 85(2): 101-109
Leijser LM, Steggerda SJ, de Bruïne FT, van der Grond J, Walther FJ, van Wezel-Meijler G.
Brain imaging findings in very preterm infants throughout the neonatal period: Part II.
Relation with perinatal clinical data. Early Hum Dev 2009; 85(2): 111-115
Steggerda SJ, Leijser LM, Wiggers-de Bruïne FT, van der Grond J, Walther FJ, van Wezel- Meijler G. Cerebellar injury in preterm infants: incidence and findings on US and MRI.
Radiology 2009; 252(1): 190-199
Leijser LM, Srinivasan L, Rutherford MA, van Wezel-Meijler G, Counsell SJ, Allsop JM, Cowan FM. Frequently encountered cranial ultrasound features in the white matter of preterm infants: correlation with MRI. Eur J Paediatr Neurol 2009; 13(4): 317-326
List of publications
330
Leijser LM, Liauw L, Veen S, de Boer IP, Walther FJ, van Wezel-Meijler G. Comparing brain white matter on sequential cranial ultrasound and MRI in very preterm infants.
Neuroradiology 2008; 50(9): 799-811
Leijser LM, Vein AA, Liauw L, Strauss T, Veen S, Wezel-Meijler G. Prediction of short-term neurological outcome in full-term neonates with hypoxic-ischaemic encephalopathy based on combined use of electroencephalogram and neuro-imaging. Neuropediatrics 2007; 38(5): 219-227
Soares-Fernandes JP, Teixeira-Gomes R, Cruz R, Ribeiro M, Magalhães Z, Rocha JF, Leijser LM. Neonatal pyruvate dehydrogenase deficiency due to a R302H mutation in the PDHA1 gene: MRI findings. Pediatr Radiol 2008; 38(5): 559-562
Leijser LM, de Vries LS, Rutherford MA, Manzur AY, Groenendaal F, de Koning TJ, van der Heide-Jalving M, Cowan FM. Cranial ultrasound in metabolic disorders presenting in the neonatal period: characteristic features and comparison with MR imaging. AJNR Am J Neuroradiol 2007; 28(7): 1223-1231
Leijser LM, Srinivasan L, Rutherford MA, Counsell SJ, Allsop JM, Cowan FM. Structural linear measurements in the newborn brain: accuracy of cranial ultrasound compared to MRI. Pediatr Radiol 2007; 37(7): 640-648
Leijser LM, Cowan FM. ‘State-of-the-Art’ Neonatal cranial ultrasound. Ultrasound 2007;
15(1): 6-17. Review
Liauw L, Palm-Meinders IH, van der Grond J, Leijser LM, le Cessie S, Laan LA, Heeres BC, van Buchem MA, van Wezel-Meijler G. Differentiating normal myelination from hypoxic- ischemic encephalopathy on T1-weighted MR images: a new approach. AJNR Am J Neuroradiol 2007; 28(4): 660-665
Leijser LM, de Vries LS, Cowan FM. Using cerebral ultrasound effectively in the newborn infant. Early Hum Dev 2006; 82(12): 827-835. Review
List of publications
Leijser LM, Klein RH, Veen S, Liauw L, van Wezel-Meijler G. Hyperechogenicity of the thalamus and basal ganglia in very preterm infants: radiological findings and short- term neurological outcome. Neuropediatrics 2004; 35(5): 283-289
Wagenaar GT, ter Horst SA, van Gastelen MA, Leijser LM, Mauad T, van der Velden PA, de Heer E, Hiemstra PS, Poorthuis BJ, Walther FJ. Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress. Free Radic Biol Med 2004; 36(6): 782-801
List of abbreviations
List of abbreviations
ADC Apparent diffusion coefficient AF Anterior fontanel
BG Basal ganglia
BGT Basal ganglia and/or thalamus BPD Bronchopulmonary dysplasia CBFV Cerebral blood flow velocity CI Confidence interval CP Cerebral palsy
CT Computed tomography
cUS Cranial ultrasonography / ultrasound CV Convex
DEHSI Diffuse and excessive high signal intensity (in the periventricular and/or subcortical white matter)
DTI Diffusion-tensor imaging DWI Diffusion-weighted imaging ECS Extracerebral spaces
EG-BGT Echogenicity of the basal ganglia and/or thalami region FA Fractional anisotropy
FLAIR Fluid-attenuated inversion recovery GA Gestational age
GM Grey matter HC Head circumference
HIE Hypoxic-ischaemic encephalopathy HPI Parenchymal haemorrhage
IHF Interhemispheric fissure IPE Intraparenchymal echodensity iv Intravenous
IVH Intraventricular haemorrhage LA Linear array
LSV Lenticulostriate vasculopathy LV Lateral ventricles
List of abbreviations
334
MCA Middle cerebral artery MDI Mental developmental index MF Mastoid fontanels
MR Magnetic resonance
MRI Magnetic resonance imaging NEC Necrotizing enterocolitis NPV Negative predictive value OR Odds ratio
PA Phased array
PDA Patent ductus arteriosus
PDI Psychomotor developmental index PF Posterior fontanel
PHVD Post-haemorrhagic ventricular dilatation PI Pulsatility index
P/IVH Peri- and intraventricular haemorrhages PLIC Posterior limb of the internal capsule PMA Postmenstrual age
PPV Positive predictive value
PVE Periventricular echodensities / echogenicity PVHI Periventricular haemorrhagic infarction PVL Periventricular leukomalacia
PWML Punctate white matter lesions RDS Respiratory distress syndrome RI Resistance index
ROI Region of interest SI Signal intensity SNR Signal-to-noise ratio TE Echo time
TEA Term equivalent age
TORCH Toxoplasmosis, Other, Rubella, Cytomegalovirus, Herpes (includingParvo B19) TR Repetition time
TW Temporal windows WM White matter
Authors and affiliations
Authors and affiliations
From the department of Paediatrics, division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands:
Lara Leijser, Gerda van Wezel-Meijler, Sylke Steggerda, Frans Walther, Sylvia Veen, Inge de Boer, Richard Klein, Ankie van Zuijlen, Andrea van Steenis
From the department of Radiology, division of Neuroradiology, Leiden University Medical Center, Leiden, the Netherlands:
Francisca de Bruïne, Jeroen van der Grond, Lishya Liauw
From the departments of Paediatrics and Neonatal Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom:
Frances Cowan
From the department of Imaging Sciences, Robert Steiner MR Unit, MRC Clinical Sciences Center, Hammersmith Hospital, Imperial College London, London, United Kingdom:
Mary Rutherford, Latha Srinivasan, Serena Counsell, Joanna Allsop
From the department of Neonatology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, the Netherlands:
Linda de Vries
