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UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)

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Congenitalhypothyroidism.nl

Kempers, M.J.E.

Publication date

2006

Link to publication

Citation for published version (APA):

Kempers, M. J. E. (2006). Congenitalhypothyroidism.nl.

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Contents s

Chapterr 1 General introduction and outline of the thesis

1.11 Preface 1.22 Thyroidology

1.2.11 Macroscopic and microscopic anatomy 1.2.22 The thyroid's regulatory system

1.2.33 Development of the thyroid gland and its regulatory system 1.2.44 The thyroid hormone receptor

1.2.55 Iodothyronine deiodinases 1.2.66 Thyroid function determinants

1.2.77 Thyroid hormone and the maternahplacental-fetal unit 1.2.88 Thyroid hormone and brain development

1.33 Congenital hypothyroidism 1.3.11 Neonatal screening 1.3.22 Incidence 1.3.33 Diagnosis

1.3.44 Clinical and molecular characteristics of thyroidal, centrall and peripheral congenital hypothyroidism 1.3.55 Treatment

1.3.66 Outcome 1.44 Outline of the thesis

Chapterr 2 The Dutch neonatal screening

2.11 Neonatal screening for congenital hypothyroidism basedd on thyroxine, thyrotropin and thyroxine-bindingg globulin: Potential and pitfalls

Chapterr 3 Thyroid dysfunction as a consequence of (inadequatelyy treated) maternal Graves' disease

3.11 Central congenital hypothyroidism due to gestational hyperthyroidism:: Detection where prevention failed

3.22 Loss of integrity of thyroid morphology and function in children bornn to mothers with inadequately treated Graves' disease

Chapterr 4 Treatment aspects

4.11 Dynamics of the plasma concentrations of TSH, FT4 and T3 followingg thyroxine supplementation in congenital hypothyroidism 4.22 The fetal thyroid hormone state has long-term consequences for

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Chapterr 5 Intellectual and motor outcome 139

5.11 Intellectual and motor development of young adults with congenitall hypothyroidism diagnosed by neonatal screening 5.22 A decade of progress in neonatal screening on

congenitall hypothyroidism in The Netherlands: Cognitivee and motor outcome at 10 years of age

5.33 Mental and psychomotor developmental indices in patients with CHH born in 2002-2004: Preliminary results at the age of 1 year

Chapterr 6 Bone mineral density 177

6.11 The effect of life-long thyroxine treatment and physicall activity on bone mineral density in young adultt women with congenital hypothyroidism

Chapterr 7 Phenotypic abnormalities 191

7.11 Phenotypic abnormalities in children with congenital hypothyroidism

Chapterr 8 General Discussion, Recommendations and Future Perspectives 227

Chapterr 9 Summary 253

Colourr Figures 261 Nederlandsee samenvatting 269

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