Cover Page The handle http://hdl.handle.net/1887/61075

Rheumatoid arthritis (RA) is the most common autoimmune disease with a prevalence of 0.5 to 1% in the adult population worldwide 16. Prime characteristics of RA are inflammation

The research presented in this thesis was performed at the department of Molecular Cell Biology and the department of rheumatology, Leiden University. Medical Center, Leiden,

Not only expression levels could be affected by these SNPs but studies have shown that genetic variants influence the predicted structure of lncRNAs related to immune diseases as

Despite elevated serum levels of TNFα and IL6 in the tested RA patients (P<0.05), ex vivo isolated monocytes displayed similar H3K4me3 levels to healthy controls in the

Major efforts in understanding the contribution of genetic risk factors are currently under way with studies querying the role of genetic variation in gene expression of coding

In addition, haplotype block analyses of this risk locus shows that block 2 is significantly associated with RA, while block 3 (which includes rs17611) is not (Ref.. Similar data

Voorts kennen de meeste werkwoor- den een tonaal onderscheid tussen een conjoint vorm en een disjoint vorm; de conjoint vorm wordt alleen gebruikt als het werkwoordelijk

Since then he has been working in Ethiopia as a linguistics consultant and trainer, focusing on orthography development, dictionary making, lan- guage software, and