Adhesion signaling and tumor cell migration : a systems microscopy approach towards understanding cancer metastasis

Besides their critical role in stable cell adhesion and cell migration, integrin- mediated interactions modulate signaling by various other receptors including receptor tyrosine

Here, we describe a method for generation of 3D CS cultures based on microinjection of cell suspensions into premade gels, that has a number of features making it highly useful

4T1 mouse breast cancer cells and MCF10a human mammary epithelial cells were transduced using lentiviral shRNA or cDNA vectors and selected for integrin or E-cadherin

In chapters 2 and 3 of this thesis, the roles of a5b1 and avb3 fibronectin (FN)-binding integrins in cell motility and adhesion dynamics are discussed.. We find that when

Dit suggereert dat b3 noodzakelijk is voor MRP lokalisatie en expressie maar dat MRP niet essentieel is voor avb3-gemedieerde cel spreiding (in tegenstelling tot

Following a brief career in the pharmaceutical industry, she returned to academia to pursue a Master of Science program, Molecular Cell Biology and Bioinformatics, at the

In this thesis, the mammary adenocarcinoma cell line MTLn3 was used to study processes involved in tumor growth and metastasis and the sensitivity towards anti-cancer drugs.. This

[48] Golubovskaya V, Beviglia L, Xu LH, Earp HS, III, Craven R, Cance W, Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively