Integrin signaling modes controlling cell migration and metastasis
Truong, H.H.
Citation
Truong, H. H. (2011, October 27). Integrin signaling modes controlling cell migration and metastasis. Retrieved from https://hdl.handle.net/1887/17990
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17990
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Integrin Signaling Modes Controlling Cell Migration and Metastasis
Hoa Hoang Truong
Hoa Hoang Truong
Integrin Signaling Modes Controlling Cell Migration and Metastasis Thesis, Leiden University, 2011
ISBN: 978-90-8570-422-5
© 2011, HH Truong
No part of this thesis may be reproduced or transmitted in any form, by any means, electronic or mechanical, without prior written permission of the author.
Cover: 4T1 spheroid stained for E-cadherin (green) and Nuclei (blue) by Blox-Tox Nov. 2009
Printed by: Wohrmann print service
Integrin Signaling Modes Controlling Cell Migration and Metastasis
PROEFSCHRIFT
ter verkrijging van de graad van Doctor aan de Universiteit van Leiden op gezag van Rector Magnificus
prof.mr. P.F. van der Heijden
volgens het besluit van het College voor Promoties te verdedigen op donderdag 27 oktober 2011
klokke 16:15 uur
door
Hoa Hoang Truong
geboren te Reno, Nevada, USA in 1977
Promotie commissie
Promotor: Prof. Dr. B. van de Water Universiteit Leiden,LACDR Co-promotor: Dr. E.H.J. Danen Universiteit Leiden,LACDR Overige leden: Prof. Dr. M. Danhof Universiteit Leiden, LACDR
Prof. Dr. P. Friedl Rabdboud Universiteit Nijmegen Prof. Dr. T. Schmidt Universiteit Leiden
Dr. A. Sonnenberg Nederlands Kanker Instituut Prof. Dr. H. Spaink Universiteit Leiden
Prof. Dr. P. ten Dijke LUMC, Leiden
The studies presented in this thesis were performed in the Division of Toxicology, LACDR, Leiden University. This research was financially supported by a grant from the Dutch Cancer Society / KWF (UL 2006-3521).
Financial support for printing of this thesis came from:
- The Dutch Cancer Society, KWF
- Leiden/Amsterdam Center for Drug Research
Table of contents
Chapter 1
General introduction and scope of this thesis. 9
Chapter 2
Truong H and Danen EHJ. Integrin switching modulates cell-matrix adhesion
dynamics. Cell Adhesion and Migration 2009 29
Chapter 3
Van den Bout I, Truong HH, Huveneers S, Kuikman I, Danen EHJ, and Sonnenberg A. Identification of integrin-regulated genes. Regulation of
MacMARCKS by integrin β3 expression. Experimental Cell Research 2007 35 Chapter 4
Huveneers S, Truong H, Fassler R, Sonnenberg A, and Danen EHJ. Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion
redistribution and contractile shape. Journal of Cell Science 2008 47 Chapter 5
Huveneers S, Truong H, and Danen EHJ. Integrins: Signaling, Disease, and
Therapy International Journal of Radiation Biology 2007 59 Chapter 6
Truong HH, de Sonneville J, Ghotra VPS, Price L, Hogendoorn P, Spaink H, van de Water B, Danen EHJ. Automated microinjection of cell-polymer suspensions for high throughput quantitiative cancer invasion screens. In press-Biomaterials
71
Chapter 7
Truong HH, Ghotra VPS, Nirmala E, Le Dévédec SE, van der Helm D, Lalai R, He S, Snaar-Jagalska BE, Amiet A, Marcinkiewicz C, Vreugdenhil E, Meerman JHN, van de Water B, Danen EHJ. Integrin control of ZEB/miR-200 balance regulates tumor cell migration strategy and metastasis. Submitted for publication
87
Summary and discussion 111
Nederlandse samenvatting 121
Curriculum vitae 129
List of publications 131
