Focal adhesion kinase signaling in metastasis and breast
cancer treatment
Nimwegen, M.J. van
Citation
Nimwegen, M. J. van. (2007, March 21). Focal adhesion kinase signaling in
metastasis and breast cancer treatment. Division of Toxicology,
Leiden/Amsterdam Centre for Drug Research, Faculty of Mathematics and
Natural Sciences, Leiden University. Retrieved from
https://hdl.handle.net/1887/11415
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral
thesis in the Institutional Repository of the University
of Leiden
Downloaded from: https://hdl.handle.net/1887/11415
Note: To cite this publication please use the final published version (if
applicable).
Focal Adhesion Kinase Signaling
in Metastasis and
Breast Cancer Treatment
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus, prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 21 maart 2007 klokke 13.45 uur
door
Maria Jannetje van Nimwegen geboren te Middelharnis
op 15 februari 1979
PROMOTIECOMMISSIE
Promotor : Prof. Dr. B. van de Water Referent : Prof. Mr. Dr. R. Fodde
Overige leden : Prof. Dr. M. Danhof Prof. Dr. A.P. IJzerman Prof. Dr. P. Devilee
Prof. Dr. R. A. E. M. Tollenaar Dr. G. van der Pluijm
The study described in this thesis was supported by a grant of the Dutch Cancer Society (UL-2001-2477) and was performed at the division of Toxicology of the Leiden Amsterdam Center for Drug Research (LACDR), The Netherlands.
The printing of this thesis was financially supported by:
Dutch Cancer Society (KWF) J.E. Jurriaanse Stichting LACDR
Dr. Ir. Van de Laar Stichting
Printing: Ponsen & Looijen BV
“If I drive myself to the brink of my ability, then I don’t get stale or bored”
Dean Koontz
Chapter 1
Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
Chapter 9
General Introduction: Breast Cancer Development, Metastasis and Treatment
Focal Adhesion Kinase: A Potential Target in Cancer Therapy
Focal Adhesion Kinase (FAK) and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells
An Improved Method to Study NK-Independent Mechanisms of Breast Cancer Lung Metastasis
Requirement for Focal Adhesion Kinase in the Early Phase of Mammary Adenocarcinoma Cell Lung Metastasis Formation
Focal Adhesion Kinase (FAK) Inhibition Ameliorates Doxorubicin Resistance of Mammary Adenocarcinoma Tumors and Lung Metastases
Genome-Wide Expression Profiling of FAK-Dependent Signaling in Doxorubicin-Induced Apoptosis of Breast Tumor Cells
General Discussion and Conclusions
Nederlandse Samenvatting Publicaties
Curriculum Vitae Dankwoord
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