Focal adhesion signaling in breast cancer treatment
Ma, Y.
Citation
Ma, Y. (2009, September 16). Focal adhesion signaling in breast cancer treatment.
Retrieved from https://hdl.handle.net/1887/14003
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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FOCAL ADHESION SIGNALING IN BREAST CANCER TREATMENT
Yafeng Ma
Yafeng Ma
Focal adhesion signaling in breast cancer treatment Thesis, Leiden University, 2009
No part of this thesis may be reproduced or transmitted in any form or by any electronic, mechanical, or other means, including photocopying, microfilminging and recording, or by any information storage or retrieval system, without prior permission in writing from the copyright owner.
ISBN: 978-90-74538-70-1
Printing by: Wöhrmann Print Service
Focal Adhesion Signaling in Breast Cancer Treatment
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr.P.F.van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 16 september 2009
klokke 13.45 uur
door
Yafeng Ma
geboren te Henan, China in 1980
Promotiecommissie
Promotor: Prof.Dr. B. van de Water
Overige leden: Prof. Dr. M. Danhof (Pharmacology, LACDR, Leiden) Prof. Dr. J. Kuiper (Biopharmaceutics, LCADR, Leiden) Prof. Dr. M. Noteborn (Biological Chemistry, LIC, Leiden) Prof. Dr. H.P. Spaink (IBL, Leiden)
Dr.Ed Roos (Cell Biology, NKI, Amsterdam)
The studies presented in this thesis were performed at the Division of Toxicology, of the Leiden/Amsterdam Center for Drug Research (LACDR), Leiden. The research described here was financially supported by the Chinese Scholar Council (CSC, China) and the LACDR.
Front cover and back cover:
Along the River During the Ch'ing-ming Festival Court painters, Ch'ing Dynasty (1644-1911)
Handscroll, ink and colors on silk, 35.6 x 1152.8 cm Printing of this thesis book was financially supported by:
Leiden/Amsterdam Center for Drug Research (LACDR) Leiden University
Tebu-bio BV
CONTENTS
Chapter 1 General Introduction 7
Chapter 2 An autocrine CXCR3 activation-loop drives breast tumor cell migration and invasion through ERK and Akt signaling 37
Chapter 3 Role of Fos related antigen-1 (Fra-1) in focal adhesion kinase (FAK) mediated chemoresistance of mammary adenocarcinoma cells 57
Chapter 4 c-Jun N-terminal Kinase coordinates vincristine-induced Rho-kinase-dependent cell contractility through the Focal Adhesion-associated Scaffold Protein Paxillin 83
Chapter 5 The Serine178 residue of paxillin determines EGF- induced cell migration of metastatic breast tumor cell MTLn3 107
Chapter 6 Discussions and perspectives 125
Summary 137
Samenvatting 143 List of abbreviations
List of publications Curriculum Vitae Acknowledgements
