Focal adhesion kinase and paxillin : mediators of breast cancer cell migration
Verkoeijen, S.
Citation
Verkoeijen, S. (2011, April 7). Focal adhesion kinase and paxillin : mediators of breast cancer cell migration. Retrieved from https://hdl.handle.net/1887/16697
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Focal adhesion kinase and paxillin:
mediators of breast cancer cell migration
Saertje Verkoeijen
Focal adhesion kinase and paxillin: mediators of breast cancer cell migration Saertje Verkoeijen
Leiden, 2011
ISBN 978-90-8570-733-2
©2011, Saertje Verkoeijen. All rights reserved. No part of this thesis may be reproduced or transmitted in any form, by any means, electronic or mechanical, without prior written permission of the author.
Printed by Wöhrmann Print Service, Zutphen, the Netherlands.
Focal adhesion kinase and paxillin:
mediators of breast cancer cell migration
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 7 april 2011 klokke 13.45 uur
door
Sarah Verkoeijen
geboren te Eindhoven
in 1975
Promotiecommissie:
Promotor: Prof. Dr. B. van de Water LACDR, Leiden Overige leden: Prof. Dr. M. Danhof LACDR, Leiden
Prof. Dr. M. Smit LACDR, Amsterdam
Prof. Dr. J. Kuiper LACDR, Leiden Prof. Dr. H. Spaink Universiteit Leiden Prof. Dr. P. Hogendoorn LUMC, Leiden Dr. G. van der Pluijm LUMC, Leiden
The research described in this thesis was performed at the Division of Toxicology of Leiden/Amsterdam Center for Drug Research (LACDR), Leiden, the Netherlands.
Printing of this thesis was financially supported by Universiteit Leiden and J.E.
Jurriaanse Stichting.
TABLE OF CONTENTS
Chapter 1 7
Introduction: Breast cancer biology and adhesion signaling
Chapter 2 57
An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis
Chapter 3 77
Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation
Chapter 4 105
Role of Fos-related antigen-1 in focal adhesion kinase-mediated chemoresistance of mammary adenocarcinoma cells
Chapter 5 135
c-Jun N-terminal kinase coordinates vincristine-induced Rho-kinase- dependent cell contractility through the focal adhesion-associated scaffold protein paxillin
Chapter 6 163
Paxillin serine 178 phosphorylation determines mammary tumor cell migration and metastasis formation through regulating EGFR expression
Chapter 7 187
Discussion
Nederlandse samenvatting 199
List of publications 203
Curriculum vitae 205
Nawoord 207
