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Genetics, autoantibodies and clinical features in understanding and predicting rheumatoid arthritis

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Genetics, autoantibodies and clinical features in understanding and

predicting rheumatoid arthritis

Helm-van Mil, A.H.M. van der

Citation

Helm-van Mil, A. H. M. van der. (2006, October 26). Genetics, autoantibodies and clinical

features in understanding and predicting rheumatoid arthritis. Retrieved from

https://hdl.handle.net/1887/4929

Version:

Corrected Publisher’s Version

License:

Licence agreement concerning inclusion of doctoral thesis in the

Institutional Repository of the University of Leiden

Downloaded from:

https://hdl.handle.net/1887/4929

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LOGISTIC¬ REGRESSION¬ ANALYSES¬ REVEALED¬ THAT¬ ARTHRITIS¬ OF¬ THE¬ LARGE¬ JOINTS ¬ IN¬ PARTICULAR¬ THE¬ KNEE ¬WAS¬ASSOCIATED¬WITH¬SEVERE¬2!¬)N¬THE¬WHOLE¬GROUP¬OF¬2! PATIENTS ¬THE¬TOTAL¬NUMBER OF¬ SWOLLEN¬ JOINTS¬ AND¬ THE¬ PRESENCE¬ OF¬ KNEE¬ ARTHRITIS¬ ASSOCIATED¬ INDEPENDENTLY¬ WITH¬ THE LEVEL¬OF¬DESTRUCTION¬OF¬THE¬SMALL¬JOINTS¬2! PATIENTS¬WITH¬KNEE¬ARTHRITIS¬HAD¬HIGHER¬# REAC TIVE¬PROTEIN¬LEVELS¬THAN¬PATIENTS¬WITHOUT¬KNEE¬ARTHRITIS¬AND¬INVESTIGATING¬THE¬DISTRIBUTION OF¬ INm¬AMED¬ JOINTS¬ TOGETHER¬ WITH¬ OTHER¬ VARIABLES¬ YIELDED¬ THE¬ NUMBER¬ OF¬ SWOLLEN¬ JOINTS # REACTIVE¬PROTEIN¬LEVEL ¬PRESENCE¬OF¬ANTI ##0¬ANTIBODIES¬AND¬SYMPTOM¬DURATION¬AS¬PRE DICTORS¬FOR¬2!¬SEVERITY

#ONCLUSIONS !RTHRITIS¬OF¬LARGE¬JOINTS ¬IN¬PARTICULAR¬THE¬KNEE ¬AT¬l¬RST¬PRESENTATION¬IS¬AS

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 #HA P TER¬  AGAINST¬CYCLIC¬CITRULLINATED¬PEPTIDE¬BEFORE¬AND¬AT¬DISEASE¬ONSET ¬AND¬BY¬)G! RHEUMATOID FACTOR¬AT¬DISEASE¬ONSET¬!NN¬2HEUM¬$IS¬¬!PRIL  

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$2"¬ TYPING¬ WAS¬ PERFORMED¬ IN¬ ¬ 2!¬ PATIENTS¬ FROM¬ THE¬ ,EIDEN¬ %ARLY¬ !RTHRITIS¬ #LINIC¬ THE¬ ,EIDEN¬ %!#¬ A¬ $UTCH¬ POPULATION BASED¬ INCEPTION¬ COHORT¬

$2¬IS¬ASSOCIATED¬WITH¬ANTI ##0 NEGATIVE¬ARTHRITIS¬AND¬NOT¬WITH¬ANTI ##0 POSITIVE¬ ARTHRITIS¬ 4HESE¬ DATA¬ SHOW¬ THAT¬ DISTINCT¬ GENETIC¬ RISK¬ FACTORS¬ ARE¬

¬BUT¬ STRATIl¬CATION¬ REVEALED¬ THAT¬ THE¬ INTERACTION¬ PRIMARILY¬ ASSOCIATES¬ WITH¬ THE¬ ANTI ##0¬

¬IT¬WAS¬OBSERVED¬BY¬TWO¬DIFFERENT¬ METHODS¬ LINKAGE¬ AND¬ ASSOCIATION¬ ANALYSIS ¬ THAT¬ THE¬ 3% ALLELES¬ ARE¬ ONLY¬ A¬ RISK¬ FACTOR¬ FOR¬ 2!¬ THAT¬ IS¬

WERE¬ PROMPTLY¬ TREATED¬ WITH¬ EITHER¬ METHOTREXATE¬ OR¬ SALAZOPYRINE¬ EARLY¬ TREATMENT ¬ 4HE¬

DIFFERENT¬ SAMPLES¬ WERE¬ OBTAINED¬ FROM¬ TWO¬ DIFFERENT¬ JOINTS¬ 4HE¬ DIFFERENCES¬ IN¬ INVASIVE NESS¬ WITHIN¬ THE¬ DIFFERENT¬ SAMPLES¬ OF¬ INDIVIDUAL¬ PATIENTS¬

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