• No results found

Genetics, autoantibodies and clinical features in understanding and predicting rheumatoid arthritis

N/A
N/A
Protected

Academic year: 2021

Share "Genetics, autoantibodies and clinical features in understanding and predicting rheumatoid arthritis"

Copied!
7
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

Genetics, autoantibodies and clinical features in understanding and

predicting rheumatoid arthritis

Helm-van Mil, A.H.M. van der

Citation

Helm-van Mil, A. H. M. van der. (2006, October 26). Genetics, autoantibodies and clinical

features in understanding and predicting rheumatoid arthritis. Retrieved from

https://hdl.handle.net/1887/4929

Version:

Corrected Publisher’s Version

License:

Licence agreement concerning inclusion of doctoral thesis in the

Institutional Repository of the University of Leiden

Downloaded from:

https://hdl.handle.net/1887/4929

(2)

'ENETICS ¬!UTOANTIBODIES¬AND¬#LINICAL¬&EATURES

IN¬5NDERSTANDING¬AND¬0REDICTING¬

2HEUMATOID¬!RTHRITIS

(3)

)3".¬   

(4)
(5)
(6)
(7)

Referenties

GERELATEERDE DOCUMENTEN

$2"¬ TYPING¬ WAS¬ PERFORMED¬ IN¬ ¬ 2!¬ PATIENTS¬ FROM¬ THE¬ ,EIDEN¬ %ARLY¬ !RTHRITIS¬ #LINIC¬ THE¬ ,EIDEN¬ %!#¬ A¬ $UTCH¬ POPULATION BASED¬ INCEPTION¬ COHORT¬

$2¬IS¬ASSOCIATED¬WITH¬ANTI ##0 NEGATIVE¬ARTHRITIS¬AND¬NOT¬WITH¬ANTI ##0 POSITIVE¬ ARTHRITIS¬ 4HESE¬ DATA¬ SHOW¬ THAT¬ DISTINCT¬ GENETIC¬ RISK¬ FACTORS¬ ARE¬

¬BUT¬ STRATIl¬CATION¬ REVEALED¬ THAT¬ THE¬ INTERACTION¬ PRIMARILY¬ ASSOCIATES¬ WITH¬ THE¬ ANTI ##0¬

¬IT¬WAS¬OBSERVED¬BY¬TWO¬DIFFERENT¬ METHODS¬ LINKAGE¬ AND¬ ASSOCIATION¬ ANALYSIS ¬ THAT¬ THE¬ 3% ALLELES¬ ARE¬ ONLY¬ A¬ RISK¬ FACTOR¬ FOR¬ 2!¬ THAT¬ IS¬

WERE¬ PROMPTLY¬ TREATED¬ WITH¬ EITHER¬ METHOTREXATE¬ OR¬ SALAZOPYRINE¬ EARLY¬ TREATMENT ¬ 4HE¬

DIFFERENT¬ SAMPLES¬ WERE¬ OBTAINED¬ FROM¬ TWO¬ DIFFERENT¬ JOINTS¬ 4HE¬ DIFFERENCES¬ IN¬ INVASIVE NESS¬ WITHIN¬ THE¬ DIFFERENT¬ SAMPLES¬ OF¬ INDIVIDUAL¬ PATIENTS¬

)N¬CONCLUSION ¬THE¬PRESENT¬STUDY¬OBSERVED¬AFTER¬CORRECTION¬FOR¬DIFFERENCES¬IN¬DISEASE¬DURA TION¬ AND¬ AUTOANTIBODY¬ STATUS¬ AN¬ INCREASE¬ IN¬ VARIATION¬

MODELS¬ THAT¬ TAKE¬ INTO¬ ACCOUNT¬ BOTH¬ GENETIC¬ AND¬ CLINICAL¬ CHARACTERISTICS¬ WILL¬ HAVE¬ TO¬ BE EVALUATED¬ IN¬ PATIENT¬ GROUPS¬ WITH¬ UNDIFFERENTIATED¬