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University of Groningen Adaptation and Modulation of Memory and Regulatory T Cells in Pregnancy Kieffer, Tom Eduard Christiaan

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University of Groningen

Adaptation and Modulation of Memory and Regulatory T Cells in Pregnancy

Kieffer, Tom Eduard Christiaan

DOI:

10.33612/diss.97355536

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Kieffer, T. E. C. (2019). Adaptation and Modulation of Memory and Regulatory T Cells in Pregnancy. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.97355536

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Adaptation and Modulation of Memory and Regulatory T Cells in Pregnancy

1. Een goed begin is het halve werk, ook in de zwangerschap (dit proefschrift). 2. Geheugen T-cellen zijn mogelijk van belang in foetale-maternale immuun

tolerantie tijdens de zwangerschap (dit proefschrift).

3. Adaptatie van T-cellen in de zwangerschap is een actief proces (dit proefschrift).

4. Niet het dempen van de maternale immuunrespons, maar het stimuleren van adequate adaptatie van het maternale immuunsysteem is de manier van immuunmodulatie die zal bijdragen aan een gezonde zwangerschap (dit proefschrift).

5. CD69 expressie op T-cellen speelt mogelijk een rol in de fysiologie van de gezonde zwangerschap (dit proefschrift).

6. Er is nog te weinig bewijs voor veilig gebruik van immuunmodulatie zoals prednisolon in de vroege zwangerschap (dit proefschrift).

7. Onderzoek naar geheugen T-cellen tijdens en na de zwangerschap is belangrijk, maar in de patiëntenpopulatie lijkt meer draagvlak voor onderzoek naar het geheugen tijdens en na de zwangerschap. 8. “The human mind treats a new idea the same way the body treats a

strange protein; it rejects it.” (Sir Peter B. Medawar)

9. “Het is niet moeilijk om te zien wat er is blijven liggen, moeilijker is het om te zien wat er allemaal al is gebeurd.” (Paul Kieffer)

10. “If I had to do it all over again? Why not, I would do it a little bit differently.” (Freddie Mercury)

Tom Kieffer

Groningen, 25 september 2019

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