University of Groningen
Adaptation and Modulation of Memory and Regulatory T Cells in Pregnancy
Kieffer, Tom Eduard Christiaan
DOI:
10.33612/diss.97355536
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
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Kieffer, T. E. C. (2019). Adaptation and Modulation of Memory and Regulatory T Cells in Pregnancy. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.97355536
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Adaptation and Modulation of Memory and
Regulatory T Cells in Pregnancy
Adaptation and Modulation of Memory and Regulatory T Cells in Pregnancy
PhD thesis, University of Groningen, with a summary in English and a summary in Dutch.
Author: Tom E.C. Kieffer
Cover design and artwork: Lisanne Koopmans | Kijk om te Zien Text lay-out: Sandra Tukker | Ridderprint Print: Ridderprint | www.ridderprint.nl ISBN (printed book): 978-94-034-1901-5
ISBN (electronic book): 978-94-034-1900-8 This PhD project was financially supported by: University Medical Center Groningen University of Groningen
Junior Scientific Masterclass, Faculty of Medicine, University of Groningen Jan Kornelis de Cock Foundation
Fonds Gezond Geboren J.C. Ruigrok Stichting
Research Foundation Obstetrics and Gynaecology, University Medical Center Groningen Copyright © 2019 by Tom Kieffer
All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without permission of the copyright owner.
Adaptation and Modulation
of Memory and Regulatory
T Cells in Pregnancy
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 25 september 2019 om 16.15 uur
door
Tom Eduard Christiaan Kieffer
geboren op 17 augustus 1991
te Delfzijl
Promotor
Prof. dr. S.A. Scherjon
Copromotores Dr. M.M. Faas Dr. J.R. Prins Beoordelingscommissie Prof. dr. F.H.J. Claas Prof. dr. J.J.H.M. Erwich Prof. dr. F.G.M. Kroese
Paranimfen
Dr. C.D. Westerlaken-van Ginkel J. Brouwer
CONTENT
1. General Introduction 11
2. Review: Memory T Cells in Pregnancy 27
Kieffer T.E.C., Laskewitz A., Scherjon S.A., Faas M.M., Prins J.R. Frontiers in Immunology 2019; 10:624
Part 1 Physiology: Adaptations of Memory and Regulatory 63
T Cells in Uncomplicated Pregnancies
3. Pregnancy persistently affects memory T cell populations 65
Kieffer T.E.C., Faas M.M., Scherjon S.A., Prins J.R. Journal of Reproductive Immunology 2017; 119:1–8
4. A Different Immune Phenotype in Decidual Tissue from Multigravid 85 Women Compared to Primigravid Women
Kieffer T.E.C., Laskewitz A., Erwich J.J.H.M., Scherjon S.A., Faas M.M., Prins J.R. (Manuscript in preparation)
5. Lower FOXP3 mRNA expression in first trimester decidual tissue 105 from uncomplicated term pregnancies with a male fetus
Kieffer T.E.C., Laskewitz A., Faas M.M., Scherjon S.A., Erwich J.J.H.M., Gordijn S.J., Prins J.R. Journal of Immunology Research 2018; 1–6
Part 2 Pathology: Altered Adaptations of Memory T Cells 117
in Preeclampsia
6. Lower activation of CD4+ memory T cells in preeclampsia 119
compared to healthy pregnancies persists postpartum
Kieffer T.E.C., Scherjon S.A., Faas M.M., Prins J.R. (Submitted)
7. Decidual Memory T Cell Subsets and Memory T Cell 141 Stimulatory Cytokines in Early- and Late-Onset Preeclampsia
Part 3 Intervention: Modulation of the Immune System 177 in Pregnancy
8. Review: Immunomodulators to treat recurrent miscarriage 179
Prins J.R., Kieffer T.E.C., Scherjon S.A. European Journal of Obstetrics and Gynecology and Reproductive Biology 2014; 181:334-337.
9. Prednisolone treatment during early pregnancy disrupts maternal 191 immune adaptation and modulates offspring development in mice
Kieffer T.E.C., Chin P.Y., Green E.S., Moldenhauer L.M., Prins J.R., Robertson S.A. (Manuscript in preparation)
10. General Discussion 217
Part 4 Appendices 233
English Summary 234
Dutch Summary (Nederlandse samenvatting) 239
List of Publications 245
List of Contributing Authors 246
Acknowledgements (Dankwoord) 250
