University of Groningen
Raynaud’s phenomenon: a mirror of autoimmune disease
van Roon, Anniek Maaike
DOI:
10.33612/diss.98238042
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Roon, A. M. (2019). Raynaud’s phenomenon: a mirror of autoimmune disease. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.98238042
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Raynaud’s phenomenon: a mirror
of autoimmune disease
Financial support for this thesis by the Junior Scientific Masterclass Groningen, Graduate School of Medical Sciences and Actelion Pharmaceutics is gratefully acknowledged. Financial support for printing of this thesis was kindly provided by NVLE Fonds, Nationale Vereniging Sjögrenpatiënten and ChipSoft.
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Raynaud’s phenomenon: a mirror of autoimmune disease
ISBN for printed version: 978-94-034-1891-9 ISBN for electronic version: 978-94-034-1890-2
© A.M. van Roon, 2019 Groningen
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
Layout and design: David de Groot, persoonlijkproefschrift.nl Printing: Ridderprint BV, ridderprint.nl
Raynaud’s phenomenon: a mirror
of autoimmune disease
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 30 oktober om 14:30 uur
door
Anniek Maaike van Roon
geboren op 11 november 1991 te Groningen
Promotores
Prof. dr. A.J. Smit Prof. dr. H. Bootsma
Copromotores
Dr. D.J. Mulder Dr. A.J. Stel
Beoordelingscommissie
Prof. dr. H. van Goor Prof. dr. A.L. Herrick Prof. dr. J.M. van Laar
Paranimfen
Saskia van de Zande Liza Milosevic
CONTENTS
Chapter 1 9
General introduction
CHAPTER 2 33
Digital ischemia during cooling is independently related to nailfold capillaroscopic pattern in patients with Raynaud’s phenomenon
CHAPTER 3 53
Longitudinal nailfold capillaroscopy tracking of microangiopathic changes in systemic sclerosis
CHAPTER 4 59
Assessing recovery after cold challenge and thumb involvement can help to rule out systemic sclerosis in patients presenting with Raynaud’s phenomenon
CHAPTER 5 71
Nailfold capillaroscopy abnormalities are associated with BMI in subjects with Raynaud’s phenomenon
CHAPTER 6 83
Abnormal nailfold capillaroscopy is common in patients with connective tissue disease and associated with abnormal pulmonary function tests
CHAPTER 7 103
Pulse Wave Velocity in Systemic Sclerosis: potential beneficial effects of bosentan on forearm arterial stiffness? An exploratory study
CHAPTER 8 123
Treatment of resistant Raynaud’s phenomenon with single-port thoracoscopic sympathicotomy: a novel minimally invasive endoscopic technique
CHAPTER 9 137
Summary, general discussion and future perspectives
Nederlandse samenvatting 160
Dankwoord 168
Curriculum vitae 175
Bibliography 176
