Characterization of B cell responses in relation to organ transplantation Heidt, S.

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Heidt, S.

Citation

Heidt, S. (2010, March 3). Characterization of B cell responses in relation to organ transplantation. Retrieved from https://hdl.handle.net/1887/15051

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/15051

Note: To cite this publication please use the final published version (if applicable).

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Publications

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Publications

165 PUBLICATIONS

1. Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes RE, van Tol MJ, Schilham MW. Extensive cross-reactivity of CD4⁺ adenovirus-specific T cells: implications for immunotherapy and gene therapy. J Virol 2003; 77 (11): 6562.

2. Waanders MM, Heidt S, Koekkoek KM, Zoet YM, Doxiadis IIN, Amir A, Heemskerk MH, Mulder A, Brand A, Roelen DL, Claas FHJ. Monitoring of indirect allorecognition:

wishful thinking or solid data? Tissue Antigens 2008; 71 (1): 1.

3. Heidt S, Roelen DL, Eijsink C, van Kooten C, Claas FHJ, Mulder A. Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin. Transplantation 2008; 86 (9): 1292.

4. Heidt S, Roelen DL, Eijsink C, Eikmans M, Claas FHJ, Mulder A. Intravenous immunoglobulin preparations have no direct effect on B cell proliferation and immunoglobulin production. Clin Exp Immunol 2009; 158 (1): 99.

5. Heidt S, Roelen DL, Eijsink C, Eikmans M, van Kooten C, Claas FHJ, Mulder A.

Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help. Clin Exp Immunol 2010; 159 (2): 199.

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Curriculum Vitae

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Curriculum Vitae

169 CURRICULUM VITAE

Sebastiaan Heidt was born on the 12th of April 1979 in Zoeterwoude, the Netherlands.

He attended secondary school at the Vlietland College in Leiden. After graduating in 1997 he started his study of Biomedical Sciences at the University of Leiden. During this study he did his practical training at the Department of Experimental Microbiology of the Leiden University Medical Center (LUMC) under supervision of Drs. D. Koppers-Lalic and Prof.

Dr. E.J.H.J. Wiertz on the subject of the interference of varicellaviruses with MHC class I presentation. After this he continued his practical training at the immunological laboratory of the Department of Paediatrics of the LUMC under supervision of Drs. B. Heemskerk and Dr. M.J.D. van Tol where he carried out a research project on adenoviruses infection after stem cell transplantation. He wrote his doctoral thesis on the subject of stem cells in regenerative medicine under supervision of Dr. M.W. Schillham. In 2003 he received his doctoral degree in Biomedical Sciences.

From July 2003 until October 2009 he worked as a PhD student under supervision of Dr.

A. Mulder, Dr. D.L. Roelen and Prof. Dr. F.H.J. Claas at the Department of Immunohae- matology and Bloodtransfusion of the LUMC, where the research that is presented in this thesis was carried out.

From October 1^st 2009 until present he has been working as a post-doctoral scientist in the laboratory of Prof. Dr. K.J. Wood at the Nuffield Department of Surgery of the Uni- versity of Oxford, United Kingdom.

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Curriculum Vitae

171 CURRICULUM VITAE

Sebastiaan Heidt werd geboren op 12 april 1979 in Zoeterwoude. Hij behaalde zijn VWO diploma in 1997 aan het Vlietland College te Leiden. Vervolgens ging hij Biomedische Wetenschappen studeren aan de Universiteit van Leiden. Tijdens deze studie liep hij stage bij de Afdeling Experimentele Microbiologie van het Leids Universitair Medisch Centrum (LUMC) onder begeleiding van Drs. D. Koppers-Lalic en Prof. Dr. E.J.H.J. Wiertz met als onderwerp de interferentie van varicellavirussen met MHC klasse I presentatie. Vervol- gens liep hij stage op het immunologisch laboratorium van de Afdeling Kindergeneeskunde van het LUMC onder begeleiding van Drs. B. Heemskerk en Dr. M.J.D. van Tol waar hij onderzoek deed naar adenovirus infecties na stamcel transplantatie. Zijn afstudeerscriptie schreef hij onder begeleiding van Dr. M.W. Schilham en had als onderwerp stamcellen in regeneratieve geneeskunde. In 2003 behaalde hij het doctoraalexamen Biomedische Wetenschappen.

Van juli 2003 tot oktober 2009 was hij werkzaam als onderzoeker in opleiding op de Afdeling Immunohaematologie en Bloedtransfusie van het LUMC onder begeleiding van Dr. A. Mulder, Dr. D.L. Roelen en Prof. Dr. F.H.J. Claas, alwaar het in dit proefschrift beschreven onderzoek werd verricht. Vanaf 1 oktober 2009 is hij werkzaam als post- doctoraal onderzoeker in het laboratorium van Prof. Dr. K.J. Wood in het Nuffield De- partment of Surgery van de Universiteit van Oxford, Verenigd Koninkrijk.