van den Berg State of the heart The promise of pluripotent stem cell-derived cardiomyocytes in disease modelling, differentiation and development Cathelijne W

Cardiomyocytes downregulate early mesodermal genes and express more cardiac specific and structural genes, while fetal heart cells have the highest levels of mature cardiac

Title: State of the heart : the promise of pluripotent stem cell-derived cardiomyocytes in disease modelling, differentiation and development.. Issue

Instead, the ability to generate pluripotent stem cells (PSCs) from adult somatic cells, known as induced pluripotent stem cells (iPSCs) 1 , and improved methods for

Here, we collected tissue from the chambers of human foetal hearts in isogenically matched combinations of atria and ventricles from either the first (T1) or

Several protocols for efficient cardiomyocyte differentiation based entirely on defined reagents were developed, various mouse and human iPSC lines were derived

From Fetus towards Adult - Maturation and functional analysis of pluripotent stem cell-de- rived cardiomyocytes.. This thesis was prepared at the Department of Anatomy &

The first reported generation of human induced pluripotent stem cells (iPS cells) and iPS cell- derived cardiomyocytes in the Netherlands.. Ward-van Oostwaard,

hPSC-CMs are relatively immature compared with cardiomyocytes from adult heart 4 (Table 1) but nevertheless can show drug-related cardiac responses that reflect QT-prolongation