• No results found

University of Groningen Resistance is Futile Sibum, Imco

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen Resistance is Futile Sibum, Imco"

Copied!
7
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Resistance is Futile

Sibum, Imco

DOI:

10.33612/diss.143830475

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Sibum, I. (2020). Resistance is Futile: The targeted delivery of antibiotics to the lungs. University of Groningen. https://doi.org/10.33612/diss.143830475

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

Resistance is Futile

The targeted delivery of antibiotics to the lungs

(3)

Paranymphs Nienke Sibum Max Beugeling

The research presented in this PhD thesis was carried out at the Department of Pharmaceutical Technology and Biopharmacy of the University of Groningen, with parts being performed at PureIMS B.V. and the Department of Clinical Pharmacy and Pharmacology of the University Medical Center Groningen.

©

Copyright 2020, I. Sibum

All rights reserved. No part of this publication may be reproduced, stored on a retrieval system, or transmitted in any form or by any means, without permission of the author.

Layout Rick Lugers

(4)

Resistance is Futile

The targeted delivery of antibiotics to the lungs

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga and in accordance with

the decision by the College of Deans. This thesis will be defended in public on Friday 20 November 2020 at 14.30 hours

by

Imco Sibum

born on 9 December 1991 in Meppel

(5)

Supervisor Prof. H. W. Frijlink Co-supervisor Dr. F. Grasmeijer Assessment Committee Prof. F. Picchioni Prof. T.S. van der Werf Prof. M. Yang

(6)

TABLE OF CONTENTS

General Introduction

Challenges for Pulmonary Delivery of High Powder

Doses

Characterization and Formulation of Isoniazid

Optimization of the Isoniazid Formulation with

L-leucine and Trileucine

Automatic Filling Equipment Allows for Increase in

Maximum Dose

Performance of an Optimized Immunoassay for the

Determination of Amikacin in Serum

General Discussion and Future Perspectives

Summary

Samenvatting

Curriculum Vitae

Dankwoord

Ch.1

Ch.2

Ch.3

Ch.4

Ch.5

Ch.6

Ch.7

A.1

A.2

A.3

A.4

8

16

66

100

130

160

174

200

208

216

220

(7)

Referenties

GERELATEERDE DOCUMENTEN

Samen met Jacques van de Ven (is er in Amsterdam ooit iets gebeurd wat jee niet weet?) gaf Willem mij de ruimte mijn eigen weg te vinden, ruimte waarin ik al diee tijd blij

vilified and segregation progressed further, but following a long separation between biological and geological sciences, awareness is now rising that geological processes related

Demonstrated in Figure 1 , the two isobaric metabolites, while separable by HPLC (panel I), are unidenti fiable on the basis of their MS/MS product ion spectra showing identical

Van het thuisfront bedank ik mijn ouders, broertje en zusje voor hun gepaste belangstelling in mijn werk (jullie begrepen dat ik niet iedere week aan mijn proefschrift herinnerd wilde

Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or privacy interests, please let the Library know,

Many studies on the immunogenicity of therapeutic antibodies indeed show an inverse correlation between anti-drug antibody levels that are developed in response to

Thee research in this thesis was conducted at the Department of HIV/AIDS and STD Research, Clusterr of Infectious Diseases of the Municipal Health Service of Amsterdam, The

Gezien de directe en indirecte mechanismen waarmee histonmodificaties chromatine en transcriptie beïnvloeden is het bestempelen van histonmodificaties als actief of